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Cui Fang Bo
Oncology
About me
Specializing in the clinical and scientific research of anticancer drugs, especially targeted therapies. Serving as the principal investigator, leading a project funded by the National Natural Science Foundation of China. As the first author, published multiple academic papers, including 6 English-language papers indexed in SCI, with the highest impact factor being 6.49.
Proficient in diseases
Treatment with anticancer drugs, especially the use of targeted therapy for tumors.
Voices
Can melanoma without metastasis avoid chemotherapy?
For patients with melanoma that has not metastasized, direct surgical removal can be performed, and chemotherapy is not necessary after surgery. Melanoma is a malignant tumor that originates from melanocytes and can occur in many parts of the body, with melanomas of the skin and mucous membranes being the most common, accounting for about 70% of all cases. Once melanoma is diagnosed, if there is no distant metastasis to other organs, curative surgical removal can be performed. Postoperative treatment mainly involves immunotherapy, not systemic chemotherapy. For patients who are diagnosed with distant organ metastasis, systemic chemotherapy and immunotherapy are required.
What are the early symptoms of rectal cancer?
Early symptoms of rectal cancer include a foreign body sensation in the anus, bloody stools, changes in stool shape, and more. Rectal cancer is a prevalent malignant tumor of the digestive tract in China, originating from the rectal mucosa. The most common pathological type is adenocarcinoma, with other pathological types being relatively rare. Patients exhibiting bloody stools or changes in stool shape should consider the possibility of rectal cancer. Patients suspected of having rectal cancer should undergo a rectal examination and colonoscopy as soon as possible. Abnormal masses in the rectum can be detected during the rectal examination and colonoscopy. Tissue can be taken from the mass for pathological diagnosis. Patients diagnosed with rectal cancer via pathology are primarily treated with surgery, and those who cannot undergo surgery should receive combined radiotherapy and chemotherapy treatment.
What should I do if I have liver cancer and a fever of 38 degrees Celsius?
Liver cancer patients experiencing a fever of 38°C can be seen in the following scenarios: The first type is tumor-related fever. In liver cancer patients, especially those in the advanced stages or with large tumors, a fever of around 38°C can occur in the absence of infection symptoms. This tumor fever is related to various mediators released into the blood by the tumor. The second type is infectious fever. Cancer patients undergoing anti-tumor treatment may experience immunosuppression and concurrent infections. This type of fever often exceeds 38.5°C but can also occur around 38°C in the early stages, often accompanied by symptoms of infection such as coughing, sputum production, abdominal pain, and diarrhea. The third type is treatment-related fever. Patients with liver cancer may experience a fever of around 38°C on the day of and several days following interventional treatments.
Is stage II-III colon cancer considered late stage?
Patients with stage II and III colon cancer are not yet considered to be in the classic advanced stages. Current oncology believes that colon cancer is categorized as stage IV and considered advanced when distant metastases occur. Common sites of metastasis for colon cancer include the liver, lungs, and bones. Stage II colon cancer patients do not have metastases to the pericolic lymph nodes, which is relatively early; stage III colon cancer patients have metastases to the pericolic lymph nodes, which is later than stage II, but as long as there are no distant metastases, it does not reach the advanced stage IV.
The significance of melanoma genetic testing
The significance of genetic testing for melanoma patients mainly involves two aspects: first, the identification of specific driver gene mutations to guide the application of targeted drugs; second, the detection of mutations in some common genes to judge the prognosis of the disease. Regarding the target gene mutations for drug selection, the commonly used ones include mutations in C-KIT, BRAF, and M-TOR. If mutations in these target genes are found, corresponding targeted drugs can be used for treatment. These drugs are generally orally administered, have relatively good efficacy, low side effects, and are suitable for the treatment of melanoma. Additionally, some genetic tests can predict the prognosis of melanoma patients based on the presence or absence of mutations.
Prostate cancer IV is stage 4.
Prostate cancer stage IV refers to stage four prostate cancer, which is a common type of male reproductive organ tumor, particularly prevalent among elderly men. Stage four prostate cancer means that the tumor is not confined to the prostate and has already shown corresponding distant metastasis. The most common sites of metastasis for prostate cancer are the bones, followed by the lungs, liver, and others. When metastasis of prostate cancer occurs, it is considered to be at a late stage, and the primary treatments include endocrine therapy, chemotherapy, etc., with a poor prognosis.
Can oral cancer be cured?
Once oral cancer is diagnosed, it is confirmed as malignant, and only a certain proportion of patients with early-stage disease can be cured. After the diagnosis of oral cancer, surgery is the preferred treatment option. It involves the removal of the clearly defined tumor within the mouth, and if necessary, dissection of the lymph nodes in the neck. After radical resection, adjunctive radiotherapy and chemotherapy are commonly used to improve disease control. Some early-stage patients can be cured after undergoing the above treatments. However, when oral cancer progresses to a certain extent, even after radical surgery and postoperative adjuvant radiotherapy and chemotherapy, the risk of recurrence and metastasis remains high, making it incurable.
Melanoma originates from which tissue?
Melanoma does not originate from any specific tissue, but from melanocytes. Therefore, melanoma can occur in any tissue where melanocytes are present. The most common sites for melanoma are the skin and mucous membranes. Additionally, because melanocytes are widely present throughout the body, melanoma can also occur in hollow organs such as the gastrointestinal tract, in skeletal muscles, and in the nervous system. Once diagnosed, melanoma needs to be treated promptly. The main treatments include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.
Can vulvar cancer be detected by B-ultrasound?
Vulvar cancer, due to its superficial location, does not require an ultrasound for detection. Vulvar cancer is a malignant tumor of the vulva, with primary squamous epithelium being the most common type. The main clinical manifestations are vulvar nodules, often accompanied by pain and significant itching. Local necrosis or infection can occur, and the lesions of vulvar cancer can be directly observed with the naked eye. However, ultrasound examination is also widely used in vulvar cancer, not for detecting the cancer itself, but for examining whether there is enlargement of the lymph nodes in the groin, abdomen, and pelvic regions, suspecting invasion by cancer cells.
Can oral cancer patients drink alcohol?
Patients who have been definitively diagnosed with oral cancer are best advised not to consume alcohol, which can be classified into the following situations: First, patients in whom oral cancer is discovered late and who are unable to undergo curative surgery still have cancerous lesions present. The vasculature of the tumor surface is relatively fragile, and drinking alcohol can cause damage to the local mucosa, leading to significant pain and even bleeding. Second, patients who have been diagnosed early with oral cancer and have undergone surgery will have scar tissue formation locally. Drinking alcohol can cause further damage to the mucosa and even irritate the scars. Third, patients who receive radiation therapy for oral cancer have normal oral mucosa that is already susceptible to radiation damage. Drinking alcohol at this time can exacerbate this type of radiation-induced mucosal damage.