Currently, the Ki67 index in colon cancer cannot be used as a predictive factor for metastasis. Ki67 reflects the proliferation index of the tumor and is related to the malignancy level of the tumor, but it is not possible to judge the risk of subsequent metastasis based on the Ki67 value.

The factors that can be used to assess the risk of postoperative metastasis in colon cancer mainly include the depth of local invasion of the colon cancer, whether there is lymph node metastasis, and the presence of certain specific gene mutations. The deeper the invasion, the higher the risk of metastasis. Patients with lymph node metastasis have a higher risk of distant recurrence and metastasis compared to those without detected lymph node metastasis.