Causes of Thyroid Cancer

Written by Gong Chun
Oncology
Updated on September 05, 2024
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Regarding the causes of thyroid cancer, they are similar to most malignant tumors. The etiology of thyroid cancer is currently unclear, but some factors have been found to be associated with the onset of thyroid cancer. The first factor is neck radiation; the thyroid is an endocrine organ that is sensitive to radiation, so radiation exposure may cause carcinogenic changes in thyroid cancer cells. The second factor is genetics; some thyroid cancers have a clear genetic predisposition, the most typical being medullary thyroid cancer, with about 25% of patients showing familial clustering, known as familial medullary thyroid cancer. The third factor is that the rapid increase in the incidence of thyroid cancer also has some reasons, with one recognized reason being advancements in early diagnostic methods, allowing for the easy detection of numerous early lesions. The fourth is iodine intake, which has been shown to be related to some benign diseases of the thyroid, but its relationship with thyroid cancer itself needs further study.

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Written by Yan Chun
Oncology
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Can occasional smoking and drinking be okay with thyroid cancer?

Thyroid cancer is a common malignant tumor in the head and neck area, and currently, the exact mechanism and etiological causes of thyroid cancer are not clearly defined in the clinic. However, some research studies indicate that there are certain factors associated with the incidence of thyroid cancer. For example, ionizing radiation, prolonged exposure can lead to the occurrence of thyroid cancer. Both insufficient and excessive iodine intake can lead to a high incidence of thyroid cancer. Genetic factors also play a significant role in the development of thyroid cancer. Excessive smoking and drinking can promote the occurrence of thyroid cancer. Therefore, heavy smoking and drinking are not recommended, but occasional smoking and drinking do not significantly impact the condition of thyroid cancer and are deemed acceptable. Moreover, for patients with thyroid cancer, treatment is primarily surgical, as radiotherapy and chemotherapy are not very sensitive anti-tumor treatments.

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Written by Yan Chun
Oncology
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Early symptoms and manifestations of thyroid cancer

Thyroid cancer is a common malignant tumor in the head and neck area. Early symptoms and signs primarily include a thyroid mass discovered incidentally during a physical examination. This type of mass grows quickly, leading to localized thyroid enlargement, and patients may experience discomfort when swallowing. Additionally, some thyroid cancer patients, due to abnormal hormone secretion, might experience unexplained skin flushing or sweating symptoms. Besides, early symptoms and manifestations of thyroid cancer are not typical, and many patients do not exhibit obvious symptoms. Instead, abnormalities in thyroid function are often incidentally found during physical examinations.

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Written by Chen Xie
Endocrinology
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What are the clinical manifestations of thyroid cancer?

For patients with thyroid cancer, the most common clinical manifestation is thyroid nodules, and most patients do not have obvious clinical symptoms, only being incidentally discovered during physical examinations. In rare cases, patients may seek medical attention due to enlarged cervical lymph nodes. As the condition progresses, the neck mass gradually enlarges, becomes firmer, and its mobility decreases during swallowing. In some rapid developments, it may invade surrounding tissues, leading to late-stage symptoms such as hoarseness, difficulty breathing, and difficulty swallowing. When the cervical sympathetic nerve is compressed, it can cause pain in the ears, occipital region, and shoulders. In the case of medullary carcinoma, which can produce serotonin and calcitonin, patients may sometimes experience symptoms such as diarrhea, palpitations, facial flushing, or decreased blood calcium levels.

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Written by Yan Chun
Oncology
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What are the early symptoms of thyroid cancer?

Thyroid cancer is a common malignant tumor in the head and neck area. The early symptoms of thyroid cancer are highly atypical, and many patients do not present clear early symptoms. Often, patients discover painless nodules in the thyroid incidentally during physical examinations; these nodules can move up and down with swallowing motions. In a minority of cases, when the nodules of early-stage thyroid cancer are large, they can cause hoarseness or coughing and choking when drinking water. Some patients might experience intermittent, hidden pain in the thyroid area during the early stages, which often resolves on its own without treatment. Besides these, in its early stages, thyroid cancer may not present other obvious symptoms. As the condition progresses, significant clinical symptoms appear only when the tumor invades surrounding structures or metastasizes to distant sites.

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Written by Gong Chun
Oncology
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Late-stage symptoms of thyroid cancer

Differentiated thyroid cancer, in its advanced stages, can exhibit noticeable symptoms due to large nodules or invasion of surrounding organs. For example, a massive nodule pressing on the trachea can cause breathing difficulties, including respiratory distress. Compression of the esophagus can lead to swallowing difficulties, and pressure on the recurrent laryngeal nerve may result in symptoms like hoarseness. Even very few benign thyroid nodules can cause edema and inflammation by compressing these nerves. Therefore, differentiation and distinctive treatment are essential, along with a pathological diagnosis. Medullary thyroid cancer also presents specific symptoms, including persistent diarrhea, endocrine syndromes, and other accompanying conditions such as pheochromocytoma, multiple mucosal neuromas, and symptoms and signs caused by parathyroid adenomas.