Causes of Thyroid Cancer

Written by Gong Chun
Oncology
Updated on September 05, 2024
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Regarding the causes of thyroid cancer, they are similar to most malignant tumors. The etiology of thyroid cancer is currently unclear, but some factors have been found to be associated with the onset of thyroid cancer. The first factor is neck radiation; the thyroid is an endocrine organ that is sensitive to radiation, so radiation exposure may cause carcinogenic changes in thyroid cancer cells. The second factor is genetics; some thyroid cancers have a clear genetic predisposition, the most typical being medullary thyroid cancer, with about 25% of patients showing familial clustering, known as familial medullary thyroid cancer. The third factor is that the rapid increase in the incidence of thyroid cancer also has some reasons, with one recognized reason being advancements in early diagnostic methods, allowing for the easy detection of numerous early lesions. The fourth is iodine intake, which has been shown to be related to some benign diseases of the thyroid, but its relationship with thyroid cancer itself needs further study.

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Written by Gong Chun
Oncology
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Early symptoms of thyroid cancer

Differentiated thyroid cancer often has no symptoms in the early stages, with only incidental palpation of nodules of various sizes and textures on the front of the neck. Some patients may find abnormalities during routine physical examinations through imaging studies, and symptoms may appear only in the later stages. The second point concerns the characteristics of medullary thyroid cancer, which exhibits specific symptoms early on, such as persistent, watery diarrhea. Additionally, this cancer involves an endocrine syndrome, where tumor cells secrete calcitonin and adrenocorticotropic hormone, potentially leading to facial flushing, elevated blood pressure, and reduced blood calcium. This may be associated with other conditions such as pheochromocytoma, multiple mucosal neuromas, and parathyroid adenomas, which can also cause corresponding symptoms.

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Written by Yan Chun
Oncology
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Will thyroid cancer spread if surgery is not performed immediately after a biopsy?

Thyroid cancer, after undergoing a fine needle biopsy, may spread if surgery cannot be performed immediately, which is a risk of the thyroid cancer biopsy. Fine needle biopsy of the thyroid is a method for obtaining histopathological results and is a gold standard for the clinical diagnosis of thyroid cancer. A biopsy is an invasive examination that causes some degree of harm to the body, hence, informed consent must be obtained from the patient before proceeding. After the biopsy, complications such as local bleeding, swelling, pain, and infection may occur, and the spread of cancer cells at the biopsy site is a significant adverse effect. Therefore, for most thyroid cancer patients, it is advisable to arrange surgery as soon as possible after a biopsy to prevent the disease from spreading.

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Written by Gong Chun
Oncology
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Early symptoms of thyroid cancer

Early symptoms of thyroid cancer: First, differentiated thyroid cancer often exhibits no symptoms in its early stages, only accidentally discovered nodules that vary in size and texture on the front of the neck. Some patients are only diagnosed during routine physical exams or through imaging studies, with clinical symptoms being relatively rare. However, more symptoms and signs may appear in the later stages. Second, medullary thyroid cancer presents some unique symptoms, such as persistent diarrhea, typically watery, and a syndrome involving the endocrine system. Patients may exhibit facial flushing, elevated blood pressure, and decreased blood calcium levels, accompanied by other conditions, such as parathyroid adenomas, multiple mucosal neuromas, and pheochromocytomas, which also manifest specific symptoms.

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Written by Yan Chun
Oncology
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What are the early symptoms of thyroid cancer?

Thyroid cancer is a common malignant tumor in the head and neck area. The early symptoms of thyroid cancer are highly atypical, and many patients do not present clear early symptoms. Often, patients discover painless nodules in the thyroid incidentally during physical examinations; these nodules can move up and down with swallowing motions. In a minority of cases, when the nodules of early-stage thyroid cancer are large, they can cause hoarseness or coughing and choking when drinking water. Some patients might experience intermittent, hidden pain in the thyroid area during the early stages, which often resolves on its own without treatment. Besides these, in its early stages, thyroid cancer may not present other obvious symptoms. As the condition progresses, significant clinical symptoms appear only when the tumor invades surrounding structures or metastasizes to distant sites.

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Oncology
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Late-stage symptoms of thyroid cancer

Differentiated thyroid cancer, in its advanced stages, can exhibit noticeable symptoms due to large nodules or invasion of surrounding organs. For example, a massive nodule pressing on the trachea can cause breathing difficulties, including respiratory distress. Compression of the esophagus can lead to swallowing difficulties, and pressure on the recurrent laryngeal nerve may result in symptoms like hoarseness. Even very few benign thyroid nodules can cause edema and inflammation by compressing these nerves. Therefore, differentiation and distinctive treatment are essential, along with a pathological diagnosis. Medullary thyroid cancer also presents specific symptoms, including persistent diarrhea, endocrine syndromes, and other accompanying conditions such as pheochromocytoma, multiple mucosal neuromas, and symptoms and signs caused by parathyroid adenomas.