Acute otitis media is caused by bacterial infection. It is an infectious inflammation of the middle ear chamber, eardrum, or mastoid cavity. Since it is a bacterial infection, the primary treatment choice is anti-infection therapy, specifically the use of antibiotics. Currently, in clinical practice under the guidance of a doctor, cephalosporin antibiotics are mainly used. At the same time, certain antibiotic ear drops should not be used, such as ofloxacin ear drops and lomefloxacin ear drops, especially in cases of acute otitis media with severe symptoms like fever and headache. Based on the condition, we also consider anti-infection treatment through infusion. Infusion refers to the intravenous use of cephalosporin antibiotics, among others. Additionally, some corticosteroids can be used to enhance the anti-infection effects.