The reasons for the non-liquefaction of liver abscesses, in my opinion, are several. The first is that the abscess is very large, and the second is the inappropriate use of antibiotics. So, what can we do to solve this problem? Firstly, liquefaction of a liver abscess takes time, and it is difficult for a large abscess or a single large abscess to be absorbed on its own. Therefore, it requires combining with percutaneous drainage. Often, even if the abscess has not fully liquefied, fine needle aspiration can still be performed to extract the pus for culture, and then identify the sensitive antibiotics. After administering a sufficient amount and course of the sensitive antibiotics, the liquefaction of the liver abscess can be accelerated and the pus can be expelled sooner.