Chronic urticaria often utilizes antihistamine medications to control symptoms, combined with Traditional Chinese Medicine (TCM) and differential diagnosis and treatment. Treating chronic urticaria generally requires long-term use of antihistamines, sometimes for two or three months, or even up to six months, a year, or more. Typically, treatment involves the combination of two or more types of antihistamines. For cases of chronic urticaria where antihistamines are ineffective, immunosuppressants may be used to adjust the body’s immune state, thus controlling the outbreaks of chronic urticaria. Chronic urticaria is a long-term, slow process that cannot be resolved quickly, so it is important to try to identify the triggering factors of chronic urticaria, or to identify specific allergens. However, finding the allergen is usually challenging because many patients with chronic urticaria have conditions that are also related to their own immune status.