Malignant manifestations of pheochromocytoma

Written by Chen Yu Fei
Neurosurgery
Updated on September 06, 2024
00:00
00:00

For patients with pheochromocytoma, when malignant pheochromocytoma occurs and leads to hypertensive crisis, it often causes severe blood pressure increases, with blood pressure even reaching over 300 mmHg. At the same time, patients present with significant symptoms such as arrhythmia, tachycardia, palpitations, and shortness of breath. Some patients may also experience prominent chest pain, labored breathing, respiratory distress, and even marked sensations of urgency or anxiety, as well as a feeling of impending doom. Additionally, some patients may experience transient vascular constriction dysfunction due to severe hypertension, leading to cerebral hemorrhage.

Other Voices

doctor image
home-news-image
Written by Chen Yu Fei
Neurosurgery
48sec home-news-image

How is pheochromocytoma diagnosed?

For the diagnosis of pheochromocytoma, further examinations need to be completed first. These examinations mainly include qualitative tests and localization tests. The qualitative tests are primarily conducted through laboratory tests to measure the levels of catecholamine-related metabolites to further determine the presence of the tumor. Localization tests are performed using abdominal ultrasound, abdominal CT, and, if necessary, high-resolution abdominal CT to pinpoint the location of the tumor. Once the qualitative and localization diagnostics are performed, it can be confirmed whether a pheochromocytoma exists and its specific location. Depending on the situation, surgery can be used to remove the tumor, in conjunction with pharmacological treatment.

doctor image
home-news-image
Written by Chen Yu Fei
Neurosurgery
43sec home-news-image

Is pheochromocytoma a cancer?

Pheochromocytoma is not a cancer. It is a special type of tumor tissue that usually originates from the neuroectodermal chromaffin tissue. It can secrete catecholamines. Based on the specific origins of the tumor cells, it can be divided into types such as parasympathetic, paraganglioma, sympathetic, and ganglioneuroma. Most often, it presents with long-term hypertension, which can cause damage to the heart, brain, and kidneys due to prolonged hypertension, or severe increases in blood pressure can lead to hypertensive brain hemorrhage, thereby endangering the patient's life. Early treatment is often necessary.

doctor image
home-news-image
Written by Chen Yu Fei
Neurosurgery
47sec home-news-image

What medication is used for pheochromocytoma?

For patients with pheochromocytoma, it is advisable to choose antihypertensive drugs during medication. Clinically, there are many types of antihypertensive drugs used to treat pheochromocytoma patients, such as alpha-adrenergic receptor blockers, beta-adrenergic receptor blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, vasodilators, catecholamine synthesis inhibitors, etc. These drugs can achieve desirable therapeutic effects. Of course, the main treatment for pheochromocytoma is through surgical methods. Only by effectively removing the tumor through surgery can a satisfactory therapeutic effect be achieved, fundamentally leading to a complete cure. (Please use medication under the guidance of a doctor.)

doctor image
home-news-image
Written by Chen Yu Fei
Neurosurgery
45sec home-news-image

Pheochromocytoma clinical manifestations

Pheochromocytoma typically presents with severe hypertension, with blood pressure even reaching above 200/140 mmHg, accompanied by significant discomfort, such as profuse sweating, chest pain, obvious difficulty in breathing, chest tightness, shortness of breath, and other clinical manifestations. Moreover, if not treated timely and effectively, it can even lead to a hypertensive crisis. It also poses a severe threat to the patient’s heart, kidneys, liver, and brain tissues. Some patients might develop cerebrovascular diseases due to very high blood pressure, such as hypertensive cerebral hemorrhage, which can threaten the patient's life.

doctor image
home-news-image
Written by Chen Yu Fei
Neurosurgery
44sec home-news-image

Can a pheochromocytoma be treated without surgery?

For pheochromocytoma, it is still best to receive surgical treatment. Conservative treatment through medication alone has limited effects. In most cases, gradually increasing blood pressure leads to serious symptoms or signs in the patient, such as palpitations, shortness of breath, labored breathing, chest pain, accompanied by profuse sweating, and even severe panic and feelings of impending doom, posing serious life-threatening risks to the patient. In terms of treatment, it is advised to prioritize surgical removal of the tumor, as this can fundamentally lead to a complete cure. Additionally, appropriate medication can be used before and after the surgery to assist in treatment.