Esophageal cancer metastasis pathways

Written by Liu Liang
Oncology
Updated on September 23, 2024
00:00
00:00

"In terms of the metastatic pathways of esophageal cancer, the first one is through the bloodstream, known as hematogenous spread. This primarily results in metastases to distant organs such as the lungs, liver, bones, etc. The second pathway is via the lymphatic system. Lymphatic spread leads to metastases in regional lymph nodes and distant lymph nodes. The third pathway is through local invasion by the tumor, where the esophageal cancer can invade nearby organs and spread. These are the pathways through which metastasis occurs."

Other Voices

doctor image
home-news-image
Written by Peng Li Bo
Oncology
1min 2sec home-news-image

Esophageal cancer T3 belongs to which stage?

For the staging of esophageal cancer, it not only depends on the T stage, but also on the N and M stages. If we are just considering the T stage, it is T3. If there are no N0 and M0 stages, it is relatively early and surgery can be considered. However, if looking only at T3 and the N stage involves lymph node involvement (N1, N2, or N3), with regional or distant lymph node metastasis, then the staging of the esophageal cancer is relatively late. Furthermore, if there is an M stage, which indicates the presence of distant organ metastasis, then it is classified as advanced stage. Therefore, the T stage alone for esophageal cancer does not determine whether it is early, intermediate, or late stage. It is necessary to look in conjunction with the N and M stages to determine the overall staging.

doctor image
home-news-image
Written by Peng Li Bo
Oncology
55sec home-news-image

Esophageal cancer screening methods

The best and clearest method for screening esophageal cancer is still gastroscopy, which can also be referred to as esophagoscopy. Endoscopic examination is very significant for this type of luminal tumor. Of course, if some people truly cannot tolerate a gastroscopic exam, they might consider initially undergoing a barium meal for the esophagus or iodized oil radiography for diagnosis. Additionally, a chest CT scan can be performed to determine whether there is narrowing in the esophageal lumen or if there is metastasis in the surrounding lymph nodes, among other issues. However, the best and most important method is certainly the esophagoscopy, or taking a biopsy of the pathological tissue under gastroscopy, which is very important for the definitive diagnosis of esophageal cancer.

doctor image
home-news-image
Written by Peng Li Bo
Oncology
53sec home-news-image

Will esophageal cancer recur after resection?

After the removal of esophageal cancer, there is indeed a possibility of recurrence. This is because not only are there tumors on the esophagus, but some mediastinal lymph nodes around the esophagus may also have metastasized. It must be acknowledged that thoracic surgeons will definitely remove the tumor completely during surgery, but they can only remove the tumors that are visible to the naked eye. Many tumor cells that cannot be seen by the naked eye are impossible to remove. If the cancer is at a relatively advanced stage, many of these invisible tumor cells cannot be eliminated, just like air is invisible but still exists. Therefore, invisible does not mean there are no cancer cells. Thus, if there is no follow-up auxiliary treatment to kill the cancer cells, the cancer may very likely recur.

doctor image
home-news-image
Written by Zhou Zi Hua
Oncology
46sec home-news-image

How can esophageal cancer be diagnosed?

The diagnosis of esophageal cancer is primarily based on symptoms. In the early stages, symptoms are generally nonspecific or only mild and typically do not attract the patient's attention. In the mid to late stages, the most common symptom is progressive difficulty swallowing. Additional diagnostic methods include esophageal radiography, MRI, and CT scans. Moreover, cytological diagnosis, endoscopic ultrasound of the esophagus, direct endoscopic examination and pathological sampling under endoscopy are utilized. The gold standard for confirmation still requires pathological or cytological diagnosis.

doctor image
home-news-image
Written by Luo Peng
Thoracic Surgery
59sec home-news-image

Symptoms of esophageal cancer spread

The most typical symptom of esophageal cancer, especially in its advanced stages, is difficulty swallowing. As esophageal cancer progresses, patients may further experience difficulty swallowing semi-liquid food, eventually leading to difficulty swallowing even water and saliva. Additionally, as the cancer develops, it might compress the trachea, resulting in symptoms like sticky sputum and difficulty in expectorating. Consequently, due to difficulties in eating, progressive severe weight loss and fatigue often occur. Furthermore, some patients may also experience chest or back pain, and in some cases, an esophageal-tracheal fistula might occur, leading to severe respiratory difficulties and intense choking. Moreover, after advanced esophageal cancer has spread, it may also cause jaundice, ascites, and can metastasize to other parts of the body, potentially resulting in various symptoms.