Does type 2 diabetes have a genetic component?

Written by Tang Zhuo

Endocrinology

Updated on March 29, 2025

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Diabetes has a high prevalence worldwide, especially type 2 diabetes, which accounts for over 90% of all cases. The pathogenesis of type 2 diabetes is very complex, including genetic susceptibility, as well as environmental factors, insulin resistance, and defects in the function of pancreatic beta cells. Thus, environmental factors are one of the influencing factors in the incidence of type 2 diabetes. There is evidence showing a familial clustering tendency among patients, but genetic factors are not the sole cause of type 2 diabetes; environmental factors also play a role. With changes in diet and lifestyle in recent years, the prevalence of type 2 diabetes has noticeably increased. Even with similar genetic backgrounds, the risk of developing type 2 diabetes varies among populations living in different areas. Therefore, diabetes can be considered a complex disease, where individuals with a genetic predisposition to diabetes, under the influence of adverse environmental conditions, can also develop elevated blood sugar levels and consequently diabetes.

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Gestational diabetes range

Gestational diabetes refers to abnormal blood sugar levels occurring during pregnancy. This term is used if the diagnosis is made during pregnancy, and does not include patients who were already diabetic before pregnancy, who are referred to as having diabetes concurrent with pregnancy. The criteria for diagnosing gestational diabetes are based on the results of the OGTT (Oral Glucose Tolerance Test) conducted between 24-28 weeks of pregnancy. According to the OGTT results, a fasting blood sugar level ≥ 5.1 mmol/L, a one-hour blood sugar level ≥ 10.0 mmol/L, or a two-hour blood sugar level ≥8.5 mmol/L, meeting any one of these criteria confirms a diagnosis of gestational diabetes.

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Can people with diabetes eat watermelon?

People with diabetes should avoid watermelon as it contains a high amount of sugar, which might exacerbate their condition and lead to complications, adversely affecting their health. Many cases of diabetes are associated with poor dietary habits, such as frequently consuming high-sugar and fried foods, which can lead to symptoms like excessive eating, drinking, urination, and weight loss. For those with mild symptoms, dietary therapy can help alleviate symptoms by adopting a low-salt and low-fat diet, coupled with aerobic exercises to aid recovery. If treatment results are not satisfactory, it may be necessary to take hypoglycemic drugs under a doctor's guidance. It is also important to develop a habit of regularly monitoring blood sugar levels to keep them within a normal range. During stable periods of the condition, choosing fruits with lower sugar content, such as figs, apples, or grapefruit, is advisable.

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How to reduce swelling in diabetic foot

How to reduce swelling in diabetic foot depends on the condition of the swelling. If the swelling is due to a wound on the diabetic foot causing localized redness and swelling, this condition needs anti-infective treatment. It is recommended to culture the wound secretion and choose a sensitive antibiotic; if the swelling is diffuse in the foot, it is also recommended to perform an ultrasound of the lower limb vessels, including arteries and veins. If this indicates poor venous return in the lower limbs or venous thrombosis, treatment to prevent thrombosis and improve venous return should also be added.

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How to treat diabetic foot?

Diabetic foot is one of the most severe complications of diabetes. It is caused by a combination of factors including peripheral vascular disease and diabetic peripheral neuropathy associated with diabetes. In such cases, treatment can involve internal medicine, interventional vascular treatment, and surgical treatment cooperatively managed by multiple vascular departments. Early treatment focuses on controlling blood sugar, improving circulation, and nourishing nerves. If ulcerations and skin breakdown have already occurred in the foot, further debridement and anti-infection treatments are necessary. It is essential to conduct an ultrasound of the lower limb vessels to assess for any vascular narrowing. If severe vascular occlusion occurs, vascular surgery may be needed to restore blood flow. In cases of severe diabetic foot with infection, surgical debridement or even amputation may be necessary. Thus, it is crucial to control blood sugar well in the early stages of diabetes to prevent these complications and potentially avoid the onset of diabetic foot.

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How to determine if you have diabetes

If a patient experiences significant symptoms of dry mouth, excessive thirst, increased urination with more foamy urine, increased appetite, but an unexplained weight loss, known as the "three polys and one low" symptoms, it is necessary to monitor fasting blood glucose. If the fasting blood glucose exceeds 7.0 mmol/L or the blood glucose two hours after a meal exceeds 11.1 mmol/L, or if there are no clear "three polys and one low" symptoms but random blood glucose levels exceed 11.1 mmol/L on two occasions, a diagnosis of diabetes can be confirmed. At the same time, it is essential to rule out secondary effects on blood sugar levels caused by infections, trauma, or the use of steroid medications. It is also recommended that the patient undergo tests for glycated hemoglobin, as well as insulin and C-peptide release tests, to further clarify the diagnosis.