The difference between severe pancreatitis and mild pancreatitis

Written by Li Qiang
Intensive Care Unit
Updated on December 01, 2024
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Generally speaking, mild pancreatitis is just a local inflammation of the pancreas, usually manifested as upper abdominal pain, nausea, vomiting, and bloating — symptoms of the gastrointestinal tract. Severe pancreatitis, however, is much more serious than mild pancreatitis. In severe pancreatitis, not only is the pain in the local pancreas area more intense and the abdominal bloating more pronounced, but there is also a lot of effusion accumulating in the abdomen. Severe pancreatitis can also affect many other organs, such as the lungs, which are most commonly affected. It can lead to patients developing acute respiratory distress syndrome, characterized by severe hypoxemia, with many patients requiring mechanical ventilation treatment. Another organ that is commonly affected is the kidney, with many patients with severe pancreatitis experiencing acute renal failure, reduced urine output, or even anuria. Severe pancreatitis can also affect the heart, brain, and other organs, leading to functional abnormalities in these organs. Therefore, besides affecting the local pancreas, severe pancreatitis can involve other important organs, resulting in multiple organ dysfunctions.

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Written by Wei Shi Liang
Intensive Care Unit
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Two major signs of severe pancreatitis

In patients with severe pancreatitis, physical examination may reveal abdominal distension with tympanic percussion sounds, prominent tenderness in the upper middle abdomen, and potentially widespread abdominal pain centered in the upper middle area. Some may exhibit rebound tenderness, moderate muscle tension is common, and a few cases may demonstrate shifting dullness. Occasionally, a mass in the upper middle abdomen can be palpated, possibly due to fluid in the lesser sac. Auscultation may reveal diminished or absent bowel sounds, accompanied by cessation of passing gas or stool, indicating features of paralytic ileus.

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Written by Wei Shi Liang
Intensive Care Unit
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Principles of Treatment for Severe Acute Pancreatitis

The treatment of severe pancreatitis requires care in an ICU, involving a multidisciplinary team. Early treatment of severe pancreatitis focuses on non-surgical management centered on organ function support, and sterile necrosis is preferably treated non-surgically. Surgical treatment is applied once necrotic infection occurs. Non-surgical treatment principally involves intensive care monitoring and mainly consists of fluid replacement, maintenance of electrolyte and acid-base balance, energy support, and prevention of local and systemic complications. Additionally, current non-surgical treatments for severe pancreatitis include bedside blood filtration, abdominal lavage, etc. Moreover, minimally invasive treatments are supplementary methods for managing severe pancreatitis, including biliary drainage, minimally invasive techniques, and treatment of infected pancreatic necrosis. Surgical intervention, involving the removal of necrotic tissue, is necessary during the infection phase.

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Written by Yang Chun Guang
Gastroenterology
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How to check for pancreatitis?

Pancreatitis can cause acute abdominal pain, along with symptoms of nausea and vomiting, and severe cases can lead to hypotensive shock. In laboratory tests, the diagnosis is generally made by assessing serum or urine amylase levels. An amylase level that exceeds three times the normal value can diagnose pancreatitis. Additionally, ultrasound and CT scans can reveal an enlarged or exuding pancreas, and the presence of a small amount of fat necrosis around the pancreas can be diagnosed as pancreatitis. The onset time of serum amylase in pancreatitis varies; typically, serum amylase begins to increase between 6 and 12 hours and starts to decline after 48 hours, and can be detected within 3 to 5 days. Lipase levels typically start to rise between 24 to 72 hours and remain elevated longer, up to 7 to 10 days. Thus, lipase has diagnostic value for later stages of pancreatitis and tends to have higher specificity compared to amylase.

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Written by Wei Shi Liang
Intensive Care Unit
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Can severe pancreatitis be cured?

Severe pancreatitis can be cured, but because its complications are severe, it may be life-threatening. Severe pancreatitis is caused by a variety of etiologies leading to local inflammation, necrosis, and infection of the pancreas, accompanied by systemic inflammatory responses and persistent organ failure. Currently, comprehensive treatment for severe pancreatitis has become very mature, but its mortality rate is still as high as 17%. Currently, with a deeper understanding of the pathology, physiology, and disease progression of severe pancreatitis, there have been advances in treatment modalities, treatment concepts, and means of organ function support for severe pancreatitis. However, the mortality rate for severe pancreatitis remains high, though it can still be cured.

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Written by Li Qiang
Intensive Care Unit
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How do you get acute severe pancreatitis?

There are many causes of acute severe pancreatitis, and the mechanisms of onset are not completely the same. Biliary pancreatitis is caused by small gallstones falling into the bile duct, becoming lodged at the distal end of the duct. At this time, the opening of the pancreatic duct is blocked, causing a disorder in pancreatic juice secretion, increasing pancreatic duct pressure, and spilling out of the pancreatic duct. This can corrode pancreatic cells and other abdominal organ cells. Alcohol and drug-induced pancreatitis is due to the direct damage of alcohol and drugs to the pancreatic cells, causing the leakage of pancreatic secretions. Overeating-induced pancreatitis is caused by consuming too much food at once, especially a high-fat diet, leading to a massive secretion of pancreatic juice. If there is an obstacle in the expulsion of this juice, it can also lead to pancreatitis. Hyperlipidemic pancreatitis is caused by excessively high blood lipid levels, which form blockages. These lipids obstruct the secretion of the pancreatic duct, causing pancreatitis. In all types of pancreatitis, the leakage of pancreatic secretions corrodes the pancreatic cells and these secretions enter the abdominal cavity, corroding abdominal organs and leading to a series of severe inflammatory responses and potentially leading to abdominal infections.