What causes lung cancer?

Written by Gong Chun
Oncology
Updated on September 13, 2024
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Lung cancer is caused by a variety of factors. Research indicates that lung cancer results from a combination of genetic defects, external and internal environmental factors, and personal factors. Numerous studies have confirmed that long-term and heavy smoking is the most significant carcinogenic factor for lung cancer. There is a positive correlation between the amount and duration of smoking and the incidence of lung cancer. The second factor is related to working in asbestos-related industries, which very much relates to the work environment, and also has a certain relation to smog. Indoor environmental pollution is also a very significant carcinogenic factor for lung cancer. This includes smoke from burning coal indoors, fumes from cooking oils in kitchens, and carcinogenic substances released by indoor decorating materials. Fourthly, internal human factors such as the immune status, metabolic abnormalities, genetic factors, and chronic lung infections are also related. The fifth factor involves irregular diet and rest habits, irritating foods, alcohol consumption, and heavy smoking.

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Written by Gong Chun
Oncology
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What is the treatment for lung cancer?

Treatment for lung cancer should be based on the pathological staging, the pathology type, the biological behavior of the lung cancer, and individualization, taking into account the patient's cardiopulmonary function and overall systemic condition to develop a personalized treatment plan. For non-small cell lung cancer and small cell lung cancer, the treatment approaches differ significantly. Therefore, it is advisable for patients to seek treatment at specialized hospitals, under the guidance of oncology specialists. Generally, treatment options for non-small cell lung cancer include surgical resection, adjunctive chemoradiation, neoadjuvant chemoradiation, targeted therapy, and immunotherapy. For small cell lung cancer, a comprehensive treatment plan combining chemoradiation, along with prophylactic cranial irradiation and other aggressive treatments, is recommended. Each individual's situation might differ, so it is important to focus on a personalized comprehensive treatment plan rather than a one-size-fits-all approach.

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Written by Gong Chun
Oncology
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How is lung cancer diagnosed?

Lung cancer is one of the malignant tumors and falls under respiratory system diseases. The gold standard for the diagnosis of malignant tumors is biopsy. Thus, lung cancer is no exception; it requires a biopsy and immunohistochemistry to determine the type of cancer and its pathological type. So how is the biopsy obtained? We can use a bronchoscope to directly observe the tumor and collect small tissue samples for pathological examination. Additionally, there is the thoracic wall lung puncture biopsy, where tissue from the tumor can be sampled using a fine needle. These samples are observed under a microscope to differentiate the pathological types and to further confirm the diagnosis.

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Written by An Yong Peng
Pulmonology
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Is coughing severe in the early stages of lung cancer?

Patients with lung cancer in the early stages may experience severe coughing, mild coughing, or no coughing symptoms at all. Many early-stage lung cancer patients have lesions located near the periphery of the lungs that do not involve the airways or other significant structures, typically resulting in no clinical symptoms. By the time clinical symptoms appear, the patient may already be in the middle or late stages of lung cancer. Additionally, it is important to note that some patients with early-stage lung cancer may also experience coughing, which can range from severe to mild, and may include coughing up blood. Such symptoms are often seen in early-stage central lung cancer, which frequently presents with cough and blood in the sputum. Therefore, older patients with a long history of smoking who suddenly develop a cough or start coughing up blood should be highly vigilant and likely need to undergo chest CT scans, bronchoscopy, and other related examinations for evaluation.

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Written by Gong Chun
Oncology
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How is lung cancer caused?

The specific causes of lung cancer are not completely clear, but there are some high-risk factors. Research has shown that lung cancer is influenced by a combination of genetic defects and internal and external environmental carcinogens. It is undeniable that long-term heavy smoking is the most important carcinogenic factor for lung cancer, with the amount and duration of smoking being positively correlated with the incidence of lung cancer. Secondly, environmental factors, such as working with asbestos or in mining areas, are also very relevant to the incidence of lung cancer. Thirdly, irregular eating habits, rest, alcohol consumption, indoor combustion, coal smoke, fumes from kitchen cooking, and carcinogenic substances released from indoor decorations and materials are also related. Fourthly, the body's internal immune status, metabolic abnormalities, genetic factors, and chronic lung infections also have a significant impact.

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Written by Gong Chun
Oncology
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Symptoms of brain metastasis from lung cancer

Brain metastasis of lung cancer is caused by hematogenous spread of lung cancer to the brain. Brain metastasis typically presents with symptoms such as headaches, nausea, and vomiting, including projectile vomiting. The headaches may be severe, and there may be abnormalities in sensory perception and motor function, possibly accompanied by seizures, mental confusion, olfactory disturbances, visual impairments, and other symptoms. The specific symptoms can vary depending on the location of the metastasis in the brain. However, most patients experience headaches, nausea, and vomiting. Individual differences are significant, and it's important to analyze the specific issues and the specific areas of the brain affected.