Can pneumonia vaccines prevent Mycoplasma infections? First, we need to understand what pneumonia vaccines are. In our country, the most commonly used pneumonia vaccines are aimed at Streptococcus pneumoniae, which are divided into polysaccharide vaccines and conjugate vaccines. Polysaccharide vaccines are mainly suitable for individuals over two years old and include the 23-valent polysaccharide vaccine. This vaccine can prevent infections caused by twenty-three serotypes that often lead to S. pneumoniae infections, with over 90% of pneumonia caused by these twenty-three serotypes. However, the 23-valent polysaccharide vaccine does not prevent infections caused by other serotypes of S. pneumoniae. Additionally, the conjugate vaccine only prevents infections caused by either seven or thirteen serotypes. Since Mycoplasma is neither a bacterium nor a virus, it cannot be prevented by pneumonia vaccines, and currently, there is no vaccine available specifically for Mycoplasma infections.