Is lymphoma hereditary?

Written by Peng Li Bo
Oncology
Updated on January 17, 2025
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Lymphoma is generally not hereditary, as it is not a genetic disease. However, I must mention that most neoplastic diseases do have some hereditary factors to some extent. The reason for this is that the cause of lymphoma is currently unclear, and it may be related to genetic mutations, which raises the issue of heredity. Another point is that heredity often refers to transmission among direct relatives. This means there could be a problem in that you might share similar environments and lifestyles, including diet. If there are factors in your diet or living environment that could trigger lymphoma, and you are both exposed to these factors, then your probability of developing lymphoma could indeed be higher than in patients without a family history, leading to such a concern.

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What is lymphoma Ki-67?

Lymphoma Ki67, also known as the proliferation index, is one of the indicators in immunohistochemistry performed after the pathological diagnosis of lymphoma. If this proliferation index is higher, it indicates that the activity of the tumor is stronger, and its proliferation is more active, thus the tumor should be given sufficient attention. Of course, active treatment should be pursued. Therefore, Ki67 reflects the activity of a tumor; if the index is very high, greater than 90%, it sometimes implies that the tumor can grow very rapidly, or not only grows significantly but might also spread to many places.

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Can lymphoma be cured?

Whether lymphoma can be cured depends on the specific pathological type of lymphoma, as there are dozens of subtypes, each with different prognoses and sensitivities to treatment. Additionally, the stage of lymphoma in patients also affects the prognosis. For example, patients with early-stage lymphoma can achieve a cure through radiotherapy and chemotherapy. However, for patients with advanced-stage lymphoma, treatment primarily involves chemotherapy, especially in cases of highly aggressive lymphoma, where it is difficult to achieve a complete cure. The goal of treatment in such cases is to alleviate pain and extend the patient's life.

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What department should lymphoma go to?

Lymphoma can be treated in the departments of hematology or oncology, where chemotherapy for lymphoma can be conducted by both. In our hospital, radiotherapy is performed in the oncology department, not by the hematology department, which only provides chemotherapy. If lymphoma has not been confirmed and there is only superficial lymph node enlargement clinically, then examinations such as ultrasound or PADCT suggest the possibility of lymphoma. In such cases, patients can visit the general surgery department for a lymph node biopsy to confirm the diagnosis. After confirmation, the patient can register in either the hematology or oncology department for further treatment.

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Lymphoma fever symptoms

Patients with lymphoma commonly exhibit symptoms such as fever, clinically referred to as B symptoms. Some patients may also experience additional B symptoms such as fatigue, sweating, or weight loss. Patients displaying these B symptoms generally have a poorer prognosis. Furthermore, lymphoma patients typically experience fever more frequently in the afternoon or evening, usually presenting with a low-grade fever. If the condition of a lymphoma patient is not controlled, their fever symptoms will recur repeatedly. Only when the condition is under control will there be an alleviation of fever symptoms. Anti-inflammatory drugs are not effective in these cases.

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Oncology
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Causes of Malignant Lymphoma

The causes of malignant lymphoma are the result of multiple factors. First, it is associated with infections by bacteria or viruses, such as the well-documented chronic infection with Helicobacter pylori, which is closely related to the occurrence of lymphoma associated with the gastric mucosa. Second, immunodeficiency conditions, like in AIDS patients or those who have been taking immunosuppressive drugs for a long period, have a higher likelihood of developing malignant lymphoma compared to the general population. Third, chemical or physical factors, such as environmental carcinogens and electromagnetic radiation, can also lead to malignant lymphoma. Other factors, such as long-term use of certain drugs like phenytoin or pseudoephedrine, and a genetic predisposition, can also be causes of malignant lymphoma.