Causes of Uremia

Written by Li Liu Sheng

Nephrology

Updated on October 19, 2024

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Uremia is a syndrome caused by the progressive development of various chronic kidney diseases, eventually leading to renal failure in patients, where the kidneys are unable to promptly eliminate excess water, various electrolytes, and toxins from the body. There are many causes of uremia; chronic nephritis, diabetic nephropathy, and hypertensive nephropathy are the most common causes. Other causes include chronic tubulointerstitial nephritis, chronic pyelonephritis, chronic obstructive nephropathy, toxic nephropathy, hereditary nephritis, renal vascular diseases, and lupus nephritis. Once uremia occurs, the preferred treatment is dialysis therapy, which can be either hemodialysis or peritoneal dialysis. Only after dialysis treatment can the life of a patient with uremia be prolonged.

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Written by Li Liu Sheng

Nephrology

52sec

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Does uremia cause fever in its early stages?

Fever is not an early clinical manifestation in patients with uremia; therefore, patients in the early stages of uremia do not exhibit fever. Typically, in the early stages of uremia, patients only show symptoms such as fatigue, poor spirit, lack of appetite, and easy fatigue, and may experience edema, such as swelling of the eyes and facial area after waking up in the morning, making it difficult for patients to open their eyes, and swelling of the lower limbs. In addition, patients also exhibit high blood pressure, such as increased systolic and diastolic pressures, which are difficult to control. Patients often exhibit clinical symptoms such as dizziness and headache. Patients also experience a significant increase in the frequency of urination at night and an increase in urine output, which are all early manifestations of uremia.

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Written by Zhou Qi

Nephrology

36sec

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How is uremia caused?

Uremia, also known as end-stage renal disease, is actually the late stage of chronic renal failure development, capable of causing long-term chronic damage to the kidneys. There are many reasons for this, and if these causes persist over a long period, continuously harming the kidneys without effective removal or control, it could eventually lead to severe renal failure, ultimately causing uremia. The causes that can chronically harm the kidneys mainly include diabetes, hypertension, chronic nephritis, polycystic kidney, urinary system stones, tumors, and other such conditions.

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Written by Li Liu Sheng

Nephrology

53sec

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Symptoms of pre-uremia

The pre-uremic stage is the period of chronic renal failure. During the pre-uremic stage, many patients may have no symptoms at all. However, some patients do experience many uncomfortable symptoms, such as back soreness and weakness, fatigue, and feeling cold easily. During this stage, patients may also experience nausea and vomiting, especially pronounced nausea after waking up in the morning, as well as weight loss. Some patients in the pre-uremic stage exhibit symptoms of edema, which can occur in the eyelids, facial area, or in both lower limbs. Additionally, patients may experience feeling cold, anemia, and an increased frequency of urination at night. Of course, some patients may also experience itching of the skin on both lower limbs.

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Written by Zhou Qi

Nephrology

1min 10sec

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What should I do about uremia heart failure?

Patients with uremia often develop complications of heart failure, which is actually the leading cause of death in patients with uremia. This type of heart failure is mainly due to the decreased ability of the kidneys to excrete water, leading to an increase in blood volume and an increased burden on the heart. It is also related to many factors such as the patient often having hypertension, anemia, coronary heart disease, etc. For such diseases, it is first necessary to assess whether the patient has excess water in the body. If there is too much water, urgent dialysis ultrafiltration is needed to remove the water. After the water is removed, the symptoms of heart failure will be significantly relieved. Secondly, it is necessary to deal with some other complications related to heart failure. For example, in the case of anemia, temporary blood transfusions or the use of erythropoiesis-stimulating agents to promote hematopoiesis can be used. Hypertension requires the use of antihypertensive drugs to control blood pressure and other comprehensive treatment measures. (Please use medications under the guidance of a doctor)

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Written by Li Fang Xiao

Internal Medicine

58sec

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Early symptoms of uremia in women

Uremia is a terminal stage of many kidney diseases. In the early stages of uremia, symptoms such as nausea and vomiting related to the gastrointestinal tract often appear. Other symptoms can include itchy skin and a dull complexion. For women, complications such as menstrual disorders and irregular menstruation may occur. In such cases, it is necessary to go to the hospital to check kidney function and determine the specific levels of creatinine and urea. If creatinine exceeds 700, it generally reaches the level of uremia, requiring renal replacement therapy such as hemodialysis or peritoneal dialysis. For uremia, it is most important to control the intake of salt and water in the diet, avoid high-salt food, and also avoid drinking too much water to prevent fluid retention in the body, thereby endangering life, as this can lead to heart failure or severe edema.