The primary differences between bacterial colds and viral colds are as follows: Firstly, their pathogens are different. Bacterial colds are caused by bacterial infections, such as Streptococcus pneumoniae and Staphylococcus aureus, which can lead to bacterial colds. Viral colds are caused by viral infections, including rhinovirus, adenovirus, and respiratory syncytial virus. Secondly, their clinical symptoms also differ. Bacterial colds may present with high fever, coughing, and purulent sputum. In contrast, viral colds rarely involve a high fever, and typically include symptoms such as sneezing, runny nose, nasal congestion, and coughing up white mucus. Thirdly, their treatment methods differ. Bacterial colds generally require anti-inflammatory medications, while viral colds are often treated with antiviral medications.