Cor pulmonale is a very common type of heart disease in the clinic, mainly caused by various etiologies leading to pulmonary arterial hypertension, which results in right ventricular hypertrophy. Typically, patients with this disease have underlying pulmonary and cardiac lesions, and it mainly causes symptoms of varying degrees, such as fever, cough, expectoration, shortness of breath, chest tightness, and even difficulty breathing. Cor pulmonale is a complex disease, and if not managed properly in clinical practice, it can lead to many complications, especially respiratory failure and heart failure. This can lead to insufficient blood and oxygen supply, causing various degrees of increased pressure in the gastric vessels or vascular spasms due to hypoxia, all of which can cause patients to experience upper gastrointestinal bleeding during severe coughing, or when consuming certain foods.