kidney cancer immunotherapy drugs

Written by Xu Chun Hua
Urology
Updated on September 19, 2024
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The immunotherapy for kidney cancer often involves the use of interferons or interleukins, and the results are generally satisfactory. The effects of radiotherapy and chemotherapy for kidney cancer are not very certain. Typically, after kidney cancer is diagnosed, radical nephrectomy is performed. During the surgery, adequate exposure is essential. The renal hilum should be ligated first to prevent cancer cells from being squeezed into the bloodstream during surgery. It is also necessary to remove the fascia and fat around the kidney, along with the lymph nodes at the renal hilum. Combining these surgical measures with immunotherapy usually yields very ideal results.

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Written by Wang Jian
Urology
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Will there be metastasis after kidney cancer removal?

Currently, all malignancies tend to metastasize. Renal cancer is a common malignant tumor of the kidney in the urinary system. Generally, patients might not exhibit any symptoms in the early stages. The most common symptoms are usually back pain and hematuria, and some patients are diagnosed due to an abdominal mass. The primary treatment for renal cancer is surgical intervention, which is considered the preferred method and is believed to be potentially curative. For patients with stage I, II, III, and IV renal cancer, the survival rates decrease progressively. Patients with stage I and II renal cancer should have follow-ups every three to six months for three consecutive years after surgery, and then annually. Patients with stage III and IV renal cancer should have follow-ups every three months for two years post-treatment, then monthly in the third year, and annually thereafter. Early detection of metastasis is crucial for timely treatment. Therefore, even after nephrectomy, renal cancer might recur, and regular follow-ups are essential.

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Written by Xu Chun Hua
Urology
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What tests are done to diagnose kidney cancer?

The typical clinical manifestations of renal cancer are hematuria, a mass, and flank pain, but these symptoms generally appear only in the middle and late stages. CT scans often play a decisive role in the diagnosis of renal cancer. Ultrasound examinations are mainly used to screen for the presence of tumors in the entire urinary system, while excretory urography can reveal compression inside the renal pelvis by the tumor, which may show irregular deformations, narrowing, or elongation. Generally speaking, CT scans are quite important for the diagnosis of renal cancer and also play a decisive role.

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Written by Zhou Qi
Nephrology
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Can renal cancer be detected by ultrasound?

Ultrasound is a type of imaging examination that can observe the size, shape, structure, texture, and the presence of masses in the organs being examined. It can be used to determine if a patient potentially has kidney-related masses, such as differentiating between a kidney cyst and kidney cancer based on differences in shape and blood supply that malignant tumors typically exhibit compared to other conditions. However, using ultrasound to diagnose kidney cancer can be inaccurate, particularly in the early stages of the disease when ultrasound may not provide a clear view, and some complex cases of kidney cancer may still be indeterminate. Therefore, patients might consider undergoing an enhanced CT scan, which offers a higher diagnostic accuracy. Additionally, a kidney biopsy and pathological examination might be necessary for a definitive diagnosis.

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Written by Li Yuan Wei
Urology
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Is nephroblastoma a type of kidney cancer?

From a broad perspective, nephroblastoma belongs to kidney cancer, but its characteristics are still different. Nephroblastoma, also known as Wilms' tumor or embryonal tumor of the kidney, is the most common malignant kidney tumor in children, generally 80% of cases occur before the age of five, with an average age of about 3.5 years. The main manifestation is an abdominal mass, most often incidentally discovered by parents or doctors. Diagnosis is generally made through renal ultrasound as an initial screening, while renal CT and MRI can clearly show the extent of the tumor and the surrounding lymph nodes and organs, and whether renal blood vessels are involved. Chest X-rays or CT scans can determine if there are any lung metastases.

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Written by Wang Jian
Urology
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Can kidney cancer that has spread to the lungs be cured?

Kidney cancer usually reaches an advanced stage by the time it metastasizes to the lungs, leading to a generally low survival rate. For early and intermediate-stage kidney cancer patients, surgical treatment is typically employed. However, in advanced stages, especially when there are lung metastases, surgical methods are often not suitable. However, if the metastatic foci are small, it is still recommended to remove them surgically. Immunotherapy can be used for lung metastases, such as using interferon or targeted therapy. Targeted therapy tends to be effective, commonly using drugs like sorafenib and sunitinib for first-line or second-line treatment of metastatic kidney cancer. Although a complete cure is not possible, these treatments can significantly prolong the patient's lifespan, improve survival rates, and alleviate symptoms.