For patients with advanced prostate cancer, endocrine therapy is primarily used. Chemotherapy is generally chosen when endocrine therapy is resistant and ineffective. The side effects of chemotherapy are similar to those of other chemotherapy treatments.

The first is the gastrointestinal side effects, such as nausea, vomiting, decreased appetite, or bloating and abdominal pain.

The second is bone marrow suppression, which leads to a decrease in white blood cells and platelets.

The side effects of chemotherapy vary with each patient's constitution and other factors. In most cases, with the support of medications for stomach protection, anti-nausea, and increasing white blood cells, the majority of patients can generally tolerate the treatment.