Tetanus vaccines generally involve an active immunization process against tetanus with a complete immunization schedule, providing effective protection for up to ten years for those who have completed the full course of prevention.

Typically, newborns must receive three doses of the DTP (diphtheria, tetanus, pertussis) vaccine, with the first dose administered at three months of age, followed by a dose each subsequent month, and booster shots at eighteen months or six years of age. If vaccinated, no further tetanus antitoxin or tetanus immunoglobulin injections are required for injuries incurred within ten years of vaccination.

If no active immunization has been done and the wound is heavily contaminated, it is crucial to promptly administer tetanus antitoxin or tetanus immunoglobulin. A skin test must be performed before using tetanus antitoxin; if the test is strongly positive, immunoglobulin should be administered for preventive treatment.