Is chemotherapy effective for late-stage rectal cancer?

Written by Yu Xu Chao
Colorectal Surgery
Updated on March 08, 2025
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Late-stage rectal cancer is primarily due to the metastasis and proliferation of cancer cells. At this stage, surgery alone cannot completely eliminate cancer cells, so chemotherapy is necessary. Chemotherapy has certain effects clinically, especially in patients who are sensitive to chemotherapy drugs, where the effects are more pronounced. This can control the spread of cancer cells in multiple locations and can, to some extent, improve patient survival rates. For patients, it is important to maintain good health, enhance their immune system, consume foods rich in high-quality proteins, and engage in appropriate exercise. Moreover, maintaining a positive mindset is beneficial for extending life. Additionally, patients can integrate traditional Chinese medicine and acupuncture as complementary therapies, which can also potentially improve postoperative survival rates.

Other Voices

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Written by Liu Liang
Oncology
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Does stage II rectal cancer require chemotherapy?

Whether a stage II colorectal cancer patient needs adjuvant chemotherapy after surgery depends on the specific circumstances. For example, stage IIA patients are classified as T3, N0, M0. The necessity of adjuvant chemotherapy for these patients should be determined based on the pathological report. If the report indicates the presence of vascular invasion, neural invasion, poor differentiation, or if microsatellite stability testing shows poor prognostic factors, then such patients should undergo postoperative adjuvant chemotherapy. If none of these conditions are present in a stage IIA patient, then postoperative adjuvant chemotherapy may not be necessary. Generally, stage IIB patients, whose tumors have penetrated the full thickness of the intestinal wall, are recommended to undergo postoperative adjuvant chemotherapy. Therefore, the specific conditions of the patient need to be considered.

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Written by Yu Xu Chao
Colorectal Surgery
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How to differentiate rectal cancer from hemorrhoids

Rectal cancer is a malignant lesion, with clinical symptoms mainly causing an increase in the frequency of bowel movements, changes in stool characteristics such as grooved stools or stools with mucus and pus and blood. Severe patients may experience abdominal pain, weight loss, anemia, and other accompanying symptoms. Generally, low-lying rectal cancer can be seen during a digital rectal examination or with an anoscope. If the cancer is located higher up, an electronic colonoscopy is needed to see the cauliflower-like mass. Hemorrhoids, on the other hand, are benign lesions often caused by improper diet or poor bowel habits, leading to pathological hypertrophy and descent of the anal cushions. They are mostly characterized by intermittent painless rectal bleeding with bright red blood, along with a feeling of heaviness and a foreign body sensation in the anus.

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Written by Gong Chun
Oncology
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Can rectal cancer be detected by ultrasound B?

Can rectal ultrasound detect it? When we perform an abdominal ultrasound for the digestive system, we might see a potential mass in the abdomen, but its specific nature cannot be clearly identified. Therefore, the definitive diagnosis of rectal cancer still relies on biopsy and pathological examination. Thus, it is recommended to go to the hospital and consult a professional oncologist for tests, such as undergoing an endoscopic biopsy or having a surgical procedure to remove and then analyze the pathology to confirm whether it is rectal cancer or not.

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Written by Gong Chun
Oncology
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Symptoms of rectal cancer recurrence

The symptoms of rectal cancer recurrence can include changes in bowel habits and stool characteristics, possibly presenting as rectal bleeding, increased frequency of bowel movements, a sensation of heaviness in the anus, and changes in stool shape, such as narrowing. The second symptom may be abdominal pain, particularly persistent and subtle pain. The third symptom involves palpable abdominal lumps or masses, especially with right-sided colon cancer. The fourth symptom is intestinal obstruction, which can occur if the bowel is blocked due to the recurrence of rectal cancer, leading to symptoms of intestinal obstruction. The fifth symptom, if the recurrent rectal cancer has metastasized, may lead to symptoms at the respective metastatic sites.

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Written by Yan Chun
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How to detect colorectal cancer early

In clinical practice, to detect colorectal cancer early, screening should be prioritized for individuals with a family history of colorectal cancer. This generally involves tests for tumor markers and colonoscopy examinations. The tumor markers include carcinoembryonic antigen, carbohydrate antigen 724, carbohydrate antigen 199, and carbohydrate antigen 125, among others. Colonoscopy examinations should be conducted annually. Furthermore, for individuals with colorectal polyps, yearly colonoscopy is especially recommended to detect early stages of colon cancer. Similarly, for individuals suffering from chronic inflammatory diseases of the colon and rectum such as ulcerative colitis or Crohn's disease, colonoscopy examinations should also be performed to facilitate early detection of colorectal cancer.