Granulomas and hemangiomas are both relatively common in clinical settings, yet they have fundamental differences. A granuloma often refers to the proliferation of macrophages and their derivative cells following inflammation in tissues or organs, forming a nodule known as a granuloma, which is actually caused by the inflammation. Hemangiomas, on the other hand, are usually tumors that form from the proliferation of blood vessel-forming cells during embryonic development, and they have no significant relationship with inflammation. Hemangiomas are also a type of benign tumor, which is the main difference between the two.