When women experience dysfunctional uterine bleeding, if this occurs during an anovulatory period, such as in adolescent or menopausal women, they generally do not experience abdominal pain. Some women have relatively regular menstrual cycles and only exhibit irregular bleeding between periods; these women still ovulate, and they may experience painful menstruation when their period comes.

Furthermore, if dysfunctional uterine bleeding persists, it can lead to a decrease in a woman's immunity. Some women may develop concurrent gynecological inflammation, such as inflammation of the endometrium or adnexa. Even if menstruation does not occur, these women may experience abdominal pain, presenting as unilateral lower abdominal pain or heaviness, and the pain may intensify during menstruation.