How to cure immune infertility

Written by Kang Jian Hua
Reproductive Center
Updated on November 16, 2024
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Immune infertility comes in many forms, such as anti-sperm antibody positivity and anti-endometrial antibody positivity, among others. The treatment for immune infertility commonly involves the use of isolating therapy, which entails using a condom during sexual intercourse. After using this method for three to six months, it can reduce further stimulation of the female by the sperm antigen, and once the antibody effect has dissipated, intercourse is timed with ovulation. At this time, conception is often possible. For immune infertility, some may choose intrauterine artificial insemination depending on the situation, which involves processing and separating the husband's semen outside the body to extract high-quality sperm for intrauterine insemination. Another method is anti-immune therapy, but the medications often have adverse side effects on the body.

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Written by Zhao Min Ying
Reproductive Medicine
1min 23sec home-news-image

What tests are done for infertility?

Couples who have lived together for more than a year and have regular sexual intercourse without using any contraception and still have not conceived are diagnosed with infertility. For men, it is referred to as sterility. Infertility requires couples to visit the reproductive medicine department for relevant infertility tests. The tests for men are simpler, primarily requiring abstinence from sexual activity for two to seven days before undergoing a semen analysis. For women, the tests vary depending on the condition but generally include the following aspects: First, blood tests related to endocrinology are conducted 2 to 4 days into menstruation. Second, from 3 to 7 days after menstruation ends, during which sexual intercourse should be avoided, tests can be conducted to check the patency of the fallopian tubes. Third, ovulation can be monitored by ultrasound from days 9 to 11 of the menstrual cycle until ovulation is confirmed. Additionally, routine gynecological examinations, including checks of the cervix and ultrasound examinations, are also conducted.

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Written by Shen Li Wen
Obstetrics and Gynecology
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What tests are done for secondary infertility?

The most common cause of secondary infertility in women is blocked fallopian tubes. In this case, a hysterosalpingography with iodine oil should be performed to understand the patency of the fallopian tubes and the specific location of the blockage, which can guide future treatment. Additionally, if a woman has abnormal vaginal discharge, a routine gynecological examination should be conducted to check for any cervical lesions. A vaginal secretion test should be performed to see if vaginal inflammation is affecting normal pregnancy. Some women experience infertility after having an abortion or induced abortion, and for these women, it's also worth considering whether uterine issues are causing secondary infertility. A hysteroscopy can be done to investigate this. When a woman experiences secondary infertility, her sexual partner or spouse should also be examined to assess sperm quality and any potential obstacles in the sperm delivery pathway.

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Written by Zhang Wei Wei
Integrative Medicine
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Can infertility ovulate?

I would like to discuss the causes of female infertility. The main causes of female infertility are ovulatory disorders and fallopian tube factors. If infertility is primarily due to fallopian tube factors, the patient does not have ovulatory disorders and can ovulate normally. Many cases of infertility are due to ovulatory disorders, which may be caused by ovarian dysfunction leading to persistent anovulation. Some are due to ovarian diseases, underdeveloped ovaries, polycystic ovary syndrome, premature ovarian failure, and functional ovarian tumors. Or it could be due to dysfunction of the hypothalamic-pituitary-ovarian axis causing anovulation. It could also be due to endocrine metabolic diseases, such as hyperfunction or hypofunction of the thyroid or adrenal cortex, which can lead to anovulation. Therefore, in women with infertility caused by fallopian tube factors, ovulation can occur; if it is caused by ovulatory disorders, it involves ineffective ovulation or an inability to ovulate.

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Written by Wang Jing Hua
Obstetrics and Gynecology
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What is infertility?

If a couple has been married for a year without using contraception, are not living separately, and have not conceived, or if there has been a history of abortion and no conception has occurred within six months of unprotected sexual activity, then this is considered infertility. Infertility can be due to female factors or male factors, with male infertility also accounting for a significant proportion. Male investigations are relatively simple, non-invasive, and also less expensive, so it is generally advisable to first conduct male tests, followed by female assessments, such as endocrine function, ovulation, uterine lining, fallopian tube examinations, or various biochemical tests, etc.

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Written by Zhang Xiu Rong
Obstetrics and Gynecology
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Is infertility immunotherapy effective?

Infertility immunotherapy is effective, first looking at the cause of infertility. If infertility arises due to immune dysfunction, immunotherapy can be employed for targeted treatment at that time. If it is caused by fallopian tube blockage, tubal hydrotubation can be performed, followed by further fallopian tube treatment. Furthermore, if infertility is caused by anovulation of the ovaries, initially monitor the follicles via ultrasound. If indeed the follicles are not ovulating, medication can be used to stimulate ovulation. If infertility is caused by endocrine disorders, it is essential to regulate the endocrine system accordingly. Therefore, whether infertility immunotherapy is useful depends on the cause. If infertility occurs due to immune dysfunction, immunotherapy can be effective. If infertility is caused by other reasons, immunotherapy will be ineffective, hence it is crucial to evaluate the situation accordingly.