Can a cervical biopsy detect cervical cancer?

Written by Li Shun Hua

Obstetrics and Gynecology

Updated on November 05, 2024

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Cervical biopsy can detect cervical cancer as long as the altered tissue is collected. However, some people have a type 3 transformation zone in the cervix, making it difficult to obtain the altered tissue, and in these cases, cervical scraping is needed. Therefore, it is best to perform the biopsy under colposcopic examination and conduct a cervical canal scraping at the same time. If there is cervical cancer, it can be detected, and generally, it will not be missed.

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Causes of cervical cancer

The causes of cervical cancer are closely related to several factors. Firstly, infection with the human papillomavirus (HPV) is highly related and is the fundamental cause of precancerous lesions and cervical cancer. Secondly, although HPV DNA is not detected in the tumor tissues of a minority of cases, particularly among older patients, epidemiological surveys indicate that early childbirth and multiple childbearing are closely related to the incidence of cervical cancer. Thirdly, it has been found that the incidence of cervical cancer in women is related to contact with high-risk men, such as those with penile cancer, prostate cancer, or those whose ex-wives had cervical cancer. Fourthly, smoking has a certain relationship with the incidence of cervical cancer as it can inhibit the body's immune function. Alcohol consumption, irregular diet, and lifestyle also have certain relationships with the incidence of cervical cancer.

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Cervical cancer treatment

For the treatment of cervical cancer, it should be based on the patient's physical condition, nutritional status, pathological staging, and pathological type to develop a comprehensive treatment plan, rather than a general, single approach. The treatment principle for cervical cancer mainly involves surgery and radiotherapy, supported by a comprehensive treatment plan that includes chemotherapy. However, the treatment plan should be based on clinical staging, age, overall health, and consider the level of technology and equipment available to formulate a suitable treatment plan. It is important to focus on individualized treatment and the method of initial treatment. Therefore, each person is different, and treatments vary from person to person and disease to disease.

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Written by Liu Jian Wei

Obstetrics and Gynecology

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Is cervical hypertrophy cervical cancer?

In clinical practice, most cases of cervical hypertrophy are not cervical cancer, but normal women do not have cervical hypertrophy. It is recommended that patients who suspect cervical hypertrophy should immediately visit the obstetrics and gynecology clinic of their local hospital, undergo a gynecological color ultrasound, and a gynecological examination to determine the cause of the cervical hypertrophy. The gynecological examination mainly relies on the doctor's visual assessment of the size of the cervix, and observation of any obvious lesions on the surface of the cervix. Additionally, gynecological ultrasound can be used to identify potential lesions in parts of the cervix that are not visible to the naked eye.

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Cervical Cancer Staging Criteria

For the staging of cervical cancer, the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) are now adopted. Staging should be done before treatment, and since the FIGO staging of the cervix mainly relies on the examination of the pelvis, it is emphasized that the pelvic examination must be performed by two senior gynecologic oncologists. The staging primarily involves assessing the size of the cervical lesion, particularly the measurement of endophytic tumors, parametrial tissue infiltration, and the status of pelvic lymph nodes. However, these stages mainly rely on radiological examinations, primarily magnetic resonance imaging (MRI), to provide objective data for staging.

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Oncology

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Cervical cancer indicators

The main indicators of cervical cancer are still the examination of the cervix and cervical canal tissues. There are obvious cancerous changes, and under the microscope pathological sections can show tendencies of cell carcinogenesis, or already developed cancer. The second is the cytological examination of cervical scrapings, which detects the presence of cancer cells. The third is the iodine test, where areas that do not stain after iodine staining indicate a lack of glycogen in the epithelium, suggesting possible lesions. The fourth is colposcopy, which may reveal suspicious cancerous areas, allowing for biopsy to confirm cancer cells. The fifth includes ultrasound, CT, MRI, etc., which can detect mass occupying lesions, all of which are indicators of cervical cancer. Of course, abnormalities in tumor markers are also considered, but the main reliance is still on the indicators from pathological examinations to determine if it's cervical cancer.