Skin itching caused by high blood sugar requires a clear understanding of the cause of the itching. On one hand, it is mainly associated with elevated blood sugar levels, and on the other hand, it may be related to peripheral neuropathy caused by diabetes. A third consideration is secondary fungal or bacterial skin infections caused by high blood sugar. For these conditions, the first step is to test blood sugar levels. If a significant increase in blood sugar is found, it is important to adjust the existing sugar-lowering plan promptly to bring blood sugar levels within an ideal range. At the same time, medications that nourish the nerves, including cobamamide and vitamin B2, can be taken. For patients with secondary skin infections, appropriate antibacterial or antifungal ointments may be given. It is also important to maintain skin cleanliness and avoid eating spicy and irritating foods. (The use of medications should be under the guidance of a physician.)