Is Kawasaki disease characterized by eye discharge?

Written by Yan Xin Liang
Pediatrics
Updated on January 29, 2025
00:00
00:00

Kawasaki disease is an autoimmune vasculitis that can affect blood vessels throughout the body and various organs, but the most severe impact is typically on the coronary arteries, which can lead to dilation of the coronary arteries or the possibility of forming coronary artery aneurysms. The disease can cause conjunctival congestion, but this is a manifestation of aseptic conjunctivitis, meaning it does not cause, nor does it result in, purulent secretions, in other words, it does not cause eye discharge. Therefore, if a patient with Kawasaki disease has purulent eye discharge, it is possible that they have a concurrent bacterial conjunctivitis. Thus, generally, eyes affected by Kawasaki disease do not have eye discharge but may appear dry and red.

Other Voices

doctor image
home-news-image
Written by Li Jiao Yan
Neonatology
48sec home-news-image

Is IgE high in Kawasaki disease?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear pathogenesis. It is speculated that certain components of infectious sources, such as superantigens, can activate CD30 T cells and CD40 ligand expression directly by binding with T cell antigen receptor fragments without going through mononuclear macrophages. Under the induction of carrier cells, there is polyclonal activation and reduced apoptosis of B08 cells, resulting in the production of large amounts of immunoglobulins such as IgG, IgM, IgA, and IgE, and cytokines. Therefore, the IgE levels in Kawasaki disease are elevated.

doctor image
home-news-image
Written by Li Jiao Yan
Neonatology
54sec home-news-image

Does Kawasaki disease affect lifespan?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, has an unclear pathogenesis. Its pathological changes primarily involve a systemic circulatory disease characterized by vasculitis. A severe complication can lead to cardiac lesions. Generally, Kawasaki disease is self-limiting and most cases have a good prognosis. However, if Kawasaki disease is not effectively treated and results in associated coronary artery aneurysms or large artery aneurysms, it could lead to acquired heart disease. Such cardiac issues could potentially affect cardiac function later on. This might impact lifespan, but if Kawasaki disease is treated aggressively and effectively, the prognosis is good and the impact on future health is minimal.

doctor image
home-news-image
Written by Shi Ji Peng
Pediatrics
57sec home-news-image

Kawasaki Disease Aspirin Side Effects

Aspirin is necessary for Kawasaki disease. Considering the pros and cons, aspirin must be used in cases of Kawasaki disease, initially in high doses. However, aspirin indeed has side effects. Some say aspirin is contraindicated for children, as its consumption can lead to Reye's Syndrome. This syndrome involves widespread mitochondrial damage following the intake of salicylate drugs during viral infection recovery, posing risks to the liver and brain. Without timely treatment, it could likely lead to liver and kidney failure, brain damage, or even death. Thus, aside from specific diseases, the use of aspirin is strictly prohibited. These specific diseases include Kawasaki disease, rheumatoid arthritis, etc. Therefore, the use of aspirin in Kawasaki disease is necessary, but it can indeed lead to some side effects.

doctor image
home-news-image
Written by Li Jiao Yan
Neonatology
1min 50sec home-news-image

Is Kawasaki disease serious?

Kawasaki disease is an etiologically unclear disease with a not well-understood pathogenesis. The principal pathological change involves inflammatory changes in the systemic blood vessels, which can affect the coronary arteries and lead to coronary artery aneurysms and dilation. Kawasaki disease is self-limiting, and most cases resolve well, with recurrences seen in 1-2% of cases. For patients without coronary artery lesions, comprehensive examinations are required 1 month, 3 months, 6 months, and 1-2 years after discharge, including physical examinations, electrocardiograms, and echocardiograms, mainly to assess the heart's condition. If not effectively treated, 15-20% may develop coronary artery aneurysms; such cases need semi-annual or annual medical check-ups. Coronary artery aneurysms often self-resolve within two years post-diagnosis, typically leaving functional abnormalities such as thickening of the vessel wall and reduced elasticity. Major artery aneurysms often do not disappear completely and can lead to thrombosis or narrowing of the vessel lumen. Kawasaki disease is one of the common causes of acquired heart disease in children; therefore, if Kawasaki disease is accompanied by severe coronary damage, it may heal well but could lead to heart disease. If it is not a severe case of Kawasaki disease, timely treatment can still result in a good recovery.

doctor image
home-news-image
Written by Li Jiao Yan
Neonatology
52sec home-news-image

What should not be eaten with Kawasaki disease?

One of the main pathological changes in Kawasaki disease is systemic vasculitis. Clinically, common symptoms include fever, high fever, recurrent fever, conjunctival congestion, significant oral mucosal congestion, strawberry tongue, enlargement of neck lymph nodes, and peeling of the hands and feet. In cases of Kawasaki disease, oral mucosal congestion is a common complication, hence during the period of Kawasaki disease, it is advised not to consume irritating, spicy, or hot foods. These might exacerbate the child's discomfort, affect their nutrient absorption, and potentially worsen the condition. Therefore, during the illness, it is preferable to focus on bland, easy-to-digest foods.