Rickets symptoms

Written by Li Jiao Yan
Neonatology
Updated on September 10, 2024
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Rickets, also known as nutritional vitamin D deficiency rickets, is a chronic nutritional disease in children caused by inadequate vitamin D in their bodies, leading to disorders in calcium and phosphorus metabolism and characterized by changes in the growth plates. Its manifestation varies with different ages. In infants under six months, especially those under three months, symptoms often include increased nervous excitability, such as being easily irritable, restless, sweating, and shaking their heads due to scalp irritation. As the condition progresses in children under six months, the primary changes are seen in the skull; the edges of the anterior fontanelle are softer, and the skull is thinner. After six months, the softening of the skull disappears, but there can be ping-pong ball-like changes around the skull, leading to a box-shaped head from seven to eight months. Gradually, beading changes form, most notably around the 7th to 10th ribs. Around the age of one, children can develop a pigeon chest deformity, and in severe cases of rickets, a horizontal depression forms at the lower edge of the thoracic cage, known as the costal groove or Harrison's groove. Due to bone softening and muscle and joint laxity, when the child begins to stand and walk, the legs may become bow-legged or X-shaped, and in severe cases, can develop into 'K'-shaped leg deformities. Once the child starts to sit and stand, general ligament laxity can cause spinal deformities. Severe hypophosphatemia leads to muscle carbohydrate metabolism disorder, resulting in overall muscle laxity, decreased muscle tone, and subsequently reduced muscle strength.

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Written by Li Jiao Yan
Neonatology
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How is rickets diagnosed?

Rickets is a chronic nutritional disease characterized by skeletal changes, resulting from insufficient Vitamin D in children, which leads to disruptions in calcium and phosphorus metabolism. Diagnosis of rickets requires a measure of Vitamin D levels, clinical manifestations, certain biochemical markers in blood, and skeletal X-ray findings. Typically, Vitamin D levels are significantly lower than usual, with the level of 25-hydroxyvitamin D3 being the most reliable diagnostic standard. However, many facilities are unable to perform this test, so some instead rely on blood biochemistry and skeletal X-rays. Currently, blood biochemistry and skeletal X-ray examinations are considered the gold standard for diagnosis.

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Written by Li Jiao Yan
Neonatology
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Early clinical manifestations of rickets

Early Symptoms of Rickets: Rickets is a chronic nutritional disease caused by a deficiency in Vitamin D, leading to disordered calcium and phosphorus metabolism and resulting in abnormal skeletal development. It primarily affects infants, especially those under six months old, with the highest occurrence in infants under three months. The general symptoms include heightened neural excitability, such as fussiness, easy irritability, sudden bouts of crying, or being so sensitive that they cry when touched. Other symptoms include excessive sweating and frequent head shaking, though these are not specific indicators of rickets. Diagnosis mainly relies on biochemical markers and Vitamin D levels, like decreased blood calcium and phosphorus levels, elevated parathyroid hormone levels, and reduced 25-hydroxy-D3. X-ray images of bones might appear normal.

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Written by Tong Peng
Pediatrics
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Can people with rickets swim?

Rickets is a metabolic disease caused by a deficiency in vitamin D, and its clinical manifestations primarily include symptoms in infants such as a square skull, night sweats, pigeon chest, eversion of the rib cage, as well as bowlegs or knock-knees. Severe cases can lead to skeletal deformities in the chest and developmental disorders. Therefore, for the treatment of children with rickets, it is necessary to intake vitamin D and calcium to promote bone development. Swimming is also a form of exercise that can enhance the absorption of calcium by the bones, which can help prevent the progression of rickets. It is also important to engage in outdoor activities and expose to sunlight, as vitamin D can be synthesized through sun exposure, effectively supplementing it. If a child's symptoms of rickets are relatively severe, it is advisable to take the child to a specialist hospital for a 25-hydroxy vitamin D test and supplement vitamin D based on the specific results.

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Written by Yao Li Qin
Pediatrics
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Can rickets be vaccinated against?

Children with rickets can be vaccinated, as rickets is not listed among the contraindications for vaccination. Rickets is a disease caused by a deficiency of vitamin D, a nutritional issue. Once diagnosed with rickets, it is essential to treat the child promptly by supplementing vitamin D. Generally, if treated early during infancy, rickets can be cured. To prevent rickets, all children should supplement with the physiological requirement of vitamin D from birth, engage in outdoor activities, and get ample sunlight to thoroughly prevent the occurrence of rickets. Rickets does not affect the administration of vaccines, nor does vaccination exacerbate the symptoms of rickets. Therefore, it is clear that children with rickets can be vaccinated.

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Written by Li Jiao Yan
Neonatology
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Can rickets be cured?

The rickets we commonly talk about is nutritional Vitamin D deficiency rickets, which is due to a deficiency of Vitamin D in the body leading to a disorder of calcium and phosphorus metabolism. This results in a systemic nutritional disease characterized by skeletal lesions. If rickets is caused by insufficient intake, it can be self-healing and is a self-limiting disease. Once infants and young children spend enough time outdoors and receive physiological doses of Vitamin D treatment, rickets can be treated. However, treatment becomes significantly challenging in cases of congenital developmental abnormalities causing skeletal lesions, or any genetic diseases that lead to Vitamin D absorption disorders. Such cases often result in severe complications, including prominent kidney dysfunction leading to further disturbances in calcium and phosphorus metabolism, as well as liver function abnormalities causing Vitamin D synthesis disorders. Therefore, it is important to understand the specific causes of Vitamin D deficiency in children, and if the deficiency is due to common reasons that can be promptly controlled, then supplementation with Vitamin D and trace elements like calcium can effectively treat the condition.