The treatment of duodenal ulcer accompanied by Helicobacter pylori infection begins primarily with anti-Helicobacter pylori therapy. The regimen includes a proton pump inhibitor, two types of antibiotics, and a bismuth agent, lasting a total of 14 days.

In addition, for duodenal ulcers, it is necessary to use acid-suppressing and stomach-protecting medications to promote gastric mobility and protect the gastric mucosa, with the treatment course lasting six weeks. At the same time, it is important to focus on a light and easily digestible diet, avoiding smoking and drinking alcohol, as well as avoiding strong tea, coffee, spicy, irritating, fried, grilled, raw, cold, and sweet foods. It is also crucial to avoid adverse emotional effects such as anxiety, depression, and stress, prevent excessive fatigue or staying up late, and it is advised to moderately increase physical activity.