The Differences between Chickenpox and Hand, Foot, and Mouth Disease

Written by Zhang Jian Kang
Infectious Disease
Updated on February 21, 2025
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Chickenpox and hand, foot, and mouth disease are common infectious diseases in young children. Chickenpox is a febrile rash disease caused by the varicella-zoster virus. Its rash mainly manifests as maculopapular, vesicular, and crusted lesions, which appear simultaneously. Generally, these are primarily seen on the face and trunk with a centripetal distribution. Hand, foot, and mouth disease is mainly caused by viruses, such as enterovirus EV71 or Coxsackievirus A16. It causes a febrile rash disease with rashes typically found on the hands, feet, and around the mouth. Rashes on the chest, back, and face are relatively rare. Thus, the main clinical presentations of hand, foot, and mouth disease and chickenpox are the different forms of rashes.

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Written by Li Ya Ping
Dermatology Department
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How is chickenpox transmitted?

Chickenpox is caused by the varicella-zoster virus infection, and it can be transmitted in two ways. One way is through the secretion of the nasopharynx, such as contagious droplets spread by coughing, sneezing, or talking, which can infect people nearby. The fluid from the blisters of chickenpox is also contagious. The primary rash of chickenpox consists of blisters, and before these blisters dry up and crust over, touching the fluid from these blisters can also transmit chickenpox. Therefore, patients with chickenpox need to be isolated until the blisters dry and form crusts before quarantine can be lifted.

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Written by Hu Qi Feng
Pediatrics
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How to treat chickenpox in children?

Chickenpox is a self-limiting disease, and when there are no complications, treatment generally involves basic care and symptomatic management. Patients should be isolated, with enhanced nursing care such as frequently changing underwear, trimming the nails of children to prevent scratching, and reducing secondary infections. It is important to maintain good ventilation in the room, provide adequate water and easily digestible food, and use antipruritic agents as appropriate to relieve itching. Antiviral drugs may be appropriately selected, antibiotics can be used for secondary infections, and corticosteroids should not be used.

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Written by Zhang Jian Kang
Infectious Disease
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The Differences between Chickenpox and Hand, Foot, and Mouth Disease

Chickenpox and hand, foot, and mouth disease are common infectious diseases in young children. Chickenpox is a febrile rash disease caused by the varicella-zoster virus. Its rash mainly manifests as maculopapular, vesicular, and crusted lesions, which appear simultaneously. Generally, these are primarily seen on the face and trunk with a centripetal distribution. Hand, foot, and mouth disease is mainly caused by viruses, such as enterovirus EV71 or Coxsackievirus A16. It causes a febrile rash disease with rashes typically found on the hands, feet, and around the mouth. Rashes on the chest, back, and face are relatively rare. Thus, the main clinical presentations of hand, foot, and mouth disease and chickenpox are the different forms of rashes.

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Written by Huang Kun Mei
Pediatrics
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Will new chickenpox blisters appear if medication is used after two days?

Medication may still cause new outbreaks of chickenpox two days after its initial use, as the typical duration of chickenpox is about a week, and new outbreaks can still occur. In this situation, it is important to avoid scratching because scratching can easily lead to skin infections and worsen the condition. Therefore, it is vital to avoid scratching. If the itching is severe, a calamine lotion can be applied to the skin. Additionally, it is crucial to consume a light, easily digestible diet, including fresh vegetables and fruits, such as broccoli, kiwi, apples, etc., and timely antiviral treatment should be carried out, as chickenpox is caused by a viral infection. (Use of medication should be under the guidance of a physician.)

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Written by Yuan Lin Yan
Infectious Disease
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What is chickenpox?

Chickenpox is a contagious disease caused by the varicella-zoster virus, commonly seen in children and prevalent in the spring season. The only source of infection is individuals with chickenpox. It spreads through respiratory droplets and direct contact. The disease is highly contagious and the general population is susceptible, but once recovered, long-lasting immunity is acquired. Clinically, symptoms may include mild fever, headache, fatigue, sore throat, cough, and loss of appetite, lasting for one to two days before the appearance of a rash. The rash first appears on the trunk and then spreads to the face and limbs. Chickenpox rash usually appears in batches, so at the same site, maculopapular rash, vesicles, and crusts can be seen. The crusts typically fall off about a week later, generally leaving no scars. Chickenpox is a self-limiting disease and typically resolves on its own in about ten days.