Clinical manifestations of breast cancer

Written by Lin Yang
Breast Surgery
Updated on February 15, 2025
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The clinical manifestations of breast cancer mostly present as painless lumps in the breast. Many early-stage breast lumps are found during physical examinations or screenings. Lumps commonly develop in the upper outer quadrant and are typically solitary on one side, though occasionally there are multiple lumps, or they may appear bilaterally. The size of the clinically observed lumps varies, with diameters of up to 5 centimeters being common. Generally, the lumps are hard in consistency, have unclear boundaries, and are not easily movable within the breast. Sometimes, the nipple may be inverted and there may be bloody discharge. Enlarged lymph nodes may also be present under the armpit.

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Breast Cancer Metastasizes to Which Locations

Breast cancer metastasis generally follows the following sites due to its anatomical structure and specific characteristics. The most common sites are the axilla, the contralateral breast, the contralateral axilla, and the areas above and below the clavicle, which is also known as the pipa bone, referring to the areas above and below the pipa bone. As for distant organs, based on the frequency or likelihood of occurrence, the most common are the lungs, bones, liver, and the brain, specifically within the head. These are referred to as the lungs, bones, liver, and head, which are the places most prone to distant organ metastasis.

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Can being angry cause breast cancer?

Frequent anger in women is associated with a higher risk of breast cancer. The causes of breast cancer are not yet fully elucidated, but recent research suggests that its development may be related to various factors. These include familial factors, reproductive factors, levels of sex hormones, and relevant genes. Frequent anger in patients can cause instability in the body's hormones, leading to exacerbated breast hyperplasia. Increased breast hyperplasia can then lead to the formation of small nodules in the breast. Due to the stimulation of estrogen in the body, these breast nodules are more likely to become cancerous. Therefore, it is important to maintain a cheerful mood, minimize anger, and eat more foods containing vitamins, as Vitamin A plays a role in protecting breast cells.

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Breast Cancer Self-Examination Method

Breast self-examination helps to detect changes in the breasts in a timely manner, and to discover breast diseases promptly. For instance, breast lumps are often found by patients themselves during self-examination. However, finding a breast lump does not necessarily mean it is breast cancer, as many conditions can present as breast lumps, such as the most common one, fibrocystic breast changes. Besides breast self-examination, early detection of breast cancer also relies on regular physical check-ups. It is recommended that women of childbearing age should develop the habit of regular breast self-examinations and routine physical check-ups, and consult a doctor promptly if abnormalities are found.

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Late-stage symptoms of breast cancer

The first symptom of advanced breast cancer is a lump in the breast, which may be larger than before, or there may be multiple lumps that are fixed to the surrounding tissues and have limited mobility. The second symptom is nipple discharge, which could be watery, serous, or milky. The third possible sign is changes in the skin, such as dimpling or an orange-peel texture. The fourth point includes the retraction of the nipple, abnormalities in the areola, and thickening and reddening of the nipple skin. The fifth point can involve pain in the breast. In advanced stages, the cancer may directly invade the nerves. Sixthly, advanced breast cancer may lead to metastases; for example, brain metastases might cause symptoms like nausea, vomiting, headaches, and dizziness. If there are bone metastases, especially multiple bone metastases, symptoms could include pain in the lower back and pain along the sciatic nerve, among others.

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Early manifestations of breast cancer

Early-stage breast cancer is primarily characterized by a single, painless small lump, which is hard with unclear boundaries and a rough surface, blending indistinguishably with surrounding tissues and difficult to move within the breast. It is usually discovered accidentally or while bathing. Swollen lymph nodes may be present, and the nipple may be inverted with possible bloody discharge. As the tumor grows, it may invade the Cooper's ligaments, causing the skin to dimple, a condition known as peau d'orange. These are all early symptoms of breast cancer. If the condition progresses, it may lead to a skin texture resembling orange peel.