Is bladder cancer hereditary?

Written by Wang Jian
Urology
Updated on September 28, 2024
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Bladder cancer is the most common malignant tumor in urology, occurring on the mucosa of the bladder and is also one of the top ten common tumors globally. The etiology of bladder cancer is complex, involving both intrinsic genetic factors and external environmental factors, which gives bladder cancer a hereditary tendency. Notable among the major risk factors are smoking and occupational exposure to aromatic amines, with 30% to 50% of bladder cancers caused by smoking. The incidence of bladder cancer significantly increases with the duration of smoking. The initial clinical manifestation of bladder cancer is usually hematuria, typically painless and intermittent gross hematuria. The presence of blood in urine should prompt further diagnostic testing to rule out malignant tumors in the bladder.

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Written by Liu Mei Fen
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What is the best medicine for bladder cancer infusion?

Bladder perfusion chemotherapy involves infusing chemotherapy drugs directly into the bladder through a catheter to control tumor growth and reduce the recurrence rate after surgery. Generally, the drugs with significant effects on bladder perfusion fall into three categories. The first category is the anthracyclines, including doxorubicin, epirubicin, and pirarubicin. The second category includes platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin. The third category is vinorelbine. According to current big data research, vinorelbine bladder perfusion tends to have a lower recurrence rate. Without postoperative bladder perfusion chemotherapy, 60%-70% of patients will eventually experience recurrence. With bladder perfusion chemotherapy, the recurrence rate can be reduced to 20%-30%.

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Diet for Bladder Cancer Patients

From the perspective of Western medicine, the diet for bladder cancer patients involves drinking plenty of water, avoiding spicy foods, and abstaining from alcohol and tobacco. Patients should also ensure they get enough vitamins by consuming fresh fruits and vegetables. Additionally, it is important to consume adequate nutrition including eggs, meat, and fish, and patients should not hold in urine. However, from the perspective of Chinese medicine, bladder cancer patients should avoid foods that induce excessive internal heat, such as lamb and seafood, and should also avoid cold or chilled foods.

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Written by Liu Liang
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Is the bladder cancer embryonic antigen high?

Carcinoembryonic antigen (CEA) is significantly elevated, mainly seen in gastrointestinal tumors, especially in colorectal cancers such as colon and rectal cancers, where CEA elevation is more pronounced. It can also be notably higher in patients with lung adenocarcinoma, and bladder cancer might show an increase in CEA as well. However, the increase in CEA is not necessarily consistent, and its diagnostic value for bladder cancer is limited due to low specificity and sensitivity, making it not very instructive. The definitive diagnosis of bladder cancer primarily involves cystoscopy and taking a biopsy to confirm the presence of cancer.

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Written by Guan Hai Fang
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How is bladder cancer diagnosed?

Firstly, imaging examinations such as ultrasound can be conducted, which if reveal tumors larger than 0.5 cm can serve as an initial screening for patients; IVU (Intravenous Urography) can show larger tumors as filling defects. Cystoscopy can also be performed by inserting a cystoscope to directly examine the bladder's shape, size, etc. If it appears round, with clear boundaries and without erosion, it is generally benign; if it has a cauliflower-like or seaweed-like appearance, it is generally malignant bladder cancer. Urine tests can also be conducted; cells from tumors found in fresh urine can lead to cytological examination of urine as an initial screening. Additionally, if conditions permit, a physical examination including a bimanual examination of the bladder can be done to preliminarily assess the tumor's size, the extent of invasion, depth, and its relationship with the pelvic wall.

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What are the symptoms of bladder cancer?

Bladder cancer's most common symptom is a consistent presence of painless gross hematuria. Some patients also exhibit frequent urination, urgency, and pain during urination as initial signs of bladder irritation. In advanced local stages, palpable pelvic tumors can be detected in patients, with symptoms such as urinary retention, lower abdominal pain, and inability to urinate. In the late stages of bladder cancer, patients may experience weight loss, back and flank pain, and signs of renal failure among other clinical manifestations.