People with AIDS may experience headaches. This can occur when individuals with AIDS develop fevers due to opportunistic infections, leading to an increase in body temperature which may cause cerebral blood vessel dilation and result in headaches. Additionally, some AIDS patients may also have intracranial opportunistic infections, such as infections with Toxoplasma, Cryptococcus, and Tuberculosis, which can cause serious meningitis or encephalitis, leading to severe and intense headaches accompanied by fever. These conditions are very dangerous and require prompt diagnosis and treatment.