Encephalitis is mainly divided into viral encephalitis, bacterial encephalitis, and tubercular meningitis, among others. Encephalitis usually causes patients to experience fever, headache, nausea, and vomiting. The cause of headaches includes the pain response due to inflammation stimulating the meninges. Moreover, these infections can cause an increase in intracranial pressure, leading to significant symptoms in patients such as headache, nausea, and vomiting. To alleviate headaches, it is important to actively treat the primary disease. This includes administering antiviral drugs for viral infections, and antibiotics for bacterial infections. If the headache is caused by increased intracranial pressure, it is crucial to actively administer dehydrating agents and drugs that lower intracranial pressure to reduce it, thereby relieving the headache. Additionally, the use of glucocorticoids can be combined to manage the treatment, suppress the inflammatory response, and alleviate pain. If the pain is significant, non-steroidal anti-inflammatory drugs may also be administered to relieve the pain. The treatment of pain in encephalitis is a comprehensive issue that requires addressing the pathogen, dehydration, reduction of intracranial pressure, and symptomatic treatment.