Early signs of diabetic nephropathy

Written by Zhou Qi
Nephrology
Updated on September 11, 2024
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Diabetic nephropathy is caused by long-term diabetes leading to damage in the small blood vessels. Generally, patients have a history of diabetes for over ten years. Diabetic nephropathy progresses through several stages. In the early stages, patients primarily exhibit microalbuminuria. Due to the presence of protein in the urine, patients may experience increased urine foam, especially noticeable with morning urination. Some patients may develop swelling in the lower limbs and around the eyelids. As the condition progresses, the amount of urine protein increases and the swelling becomes more pronounced, potentially reaching the level of nephrotic syndrome.

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Written by Zhou Qi
Nephrology
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Which department should diabetic nephropathy patients see?

Diabetic nephropathy is damage to small blood vessels caused by diabetes, and the kidneys contain a large number of small blood vessels. Therefore, it generally takes more than ten years for diabetes to damage these small blood vessels, causing kidney lesions, proteinuria, renal failure, and other clinical manifestations. This disease can be treated in departments specializing in diabetes or endocrinology, as well as in nephrology. In the early stages of diabetic nephropathy, treatment primarily involves controlling blood sugar levels, and visiting departments like diabetes or endocrinology might be more specialized in this regard. These departments are proficient in adjusting medications for blood sugar control. When patients develop significant proteinuria, the condition progresses, and it is advisable to visit nephrology. At this point, the treatment focuses on the kidney lesions, as well as managing complications caused by diabetic nephropathy.

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Written by Zhou Qi
Nephrology
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Is stage three diabetic nephropathy severe?

Stage three of diabetic nephropathy refers to patients who have persistent microalbuminuria, indicating a relatively mild state of the disease at this time. In fact, diabetic nephropathy is divided into five stages. During the first and second stages, patients generally do not exhibit specific symptoms clinically and may even test negative for proteinuria; however, an increase in kidney size and glomerular filtration rate may occur. By the third stage, patients begin to exhibit small or micro amounts of urinary albumin. The pathological damage to the kidneys at this stage is not considered particularly severe. Patients may experience hyalinization of small arteries and nodular lesions in the glomeruli. Within the staging of diabetic nephropathy, this does not constitute a particularly severe phase; however, the condition of the patients may continue to progress, leading to significant proteinuria and even renal failure.

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Written by Zhou Qi
Nephrology
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How to reduce proteinuria in diabetic nephropathy.

A major clinical feature of diabetic nephropathy is the occurrence of proteinuria, which, if the condition continues to progress, can lead to kidney failure. Controlling proteinuria in the early stages of the disease is indeed very important. In terms of treatment, it is primarily necessary to use medications or insulin to control the patient's blood sugar, as hyperglycemia is the fundamental cause of diabetic nephropathy. Additionally, these patients often also have hypertension, necessitating the use of antihypertensive drugs to control blood pressure. When the patient's kidney function is not severely impaired, ACE inhibitors or ARBs can be the preferred choice of antihypertensive drugs, as they not only control blood pressure but also reduce proteinuria. However, if the patient's serum creatinine is significantly elevated, such as over 264 µmol/L, these drugs should no longer be used. (Medications should be used under the guidance of a doctor.)

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Written by Pan Wu Shan
Nephrology
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What can diabetic nephropathy eat?

Diabetic nephropathy, as the name suggests, is a complication of the kidneys caused by long-term poor control of blood sugar in diabetes. Its most typical symptoms include significant proteinuria and potential body edema. Generally, there is no particularly good method to treat diabetic nephropathy; firstly, it is necessary to control blood sugar well, ensuring that fasting blood glucose does not exceed 7 mmol/L, and blood glucose two hours after a meal does not exceed 10 mmol/L. Additionally, some kidney-protective measures can be used to reduce urinary protein, etc. Furthermore, foods high in sugar, fried foods, and those high in starch should be avoided, such as potatoes, taro, sweet potatoes, and vermicelli, all of which should be consumed less.

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Written by Zhou Qi
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How is diabetic nephropathy treated?

The treatment of diabetic nephropathy also depends on the specific stage the patient is in. During stages one to three, the main clinical treatments include controlling blood sugar, blood pressure, and lipids. Patients with diabetes often also have these metabolic disorders, including hypertension and hyperlipidemia, which can damage the kidneys. In addition, in the early stages, some medications are often chosen to reduce the pressure on the glomeruli. For example, using ACE inhibitors or angiotensin receptor blockers (ARBs) and inhibitors of the sodium-glucose cotransporter, these drugs can also slow the progression of kidney failure. However, if the patient's condition has progressed to stage five, which is essentially equivalent to the state of uremia, the patient will then need dialysis treatment.