The characteristics of proteinuria in IgA nephropathy

Written by Zhou Qi
Nephrology
Updated on September 06, 2024
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IgA nephropathy is a pathological type of chronic glomerulonephritis, which can cause patients to exhibit symptoms such as proteinuria and hematuria. Regarding the characteristics of proteinuria, it is generally primarily glomerular proteinuria. In the classification of patients' proteinuria, glomerular proteinuria accounts for a large proportion. If IgA nephropathy presents as chronic nephritis or nephrotic syndrome, the patient's level of proteinuria will be quite severe, with significant amounts of proteinuria, where the 24-hour urinary protein quantification may exceed 1g or even reach more than 3.5g. However, not all patients with IgA nephropathy have such high levels of proteinuria; some may only have mild proteinuria.

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Written by Li Liu Sheng
Nephrology
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Can patients with IgA nephropathy eat beef?

Diet plays a very important role in the treatment of IgA nephropathy patients. For IgA nephropathy patients, the general dietary requirement is to eat a light diet, avoid spicy foods, and avoid fried foods. IgA nephropathy patients can eat beef. Beef contains animal protein, which is a high-quality protein with essential amino acids that are easily absorbed and utilized by the human body. Of course, if IgA nephropathy patients have normal kidney function, there aren't too many restrictions on their diet compared to healthy individuals. They should mainly consume fresh vegetables and fruits, and avoid pickles, salty vegetables, and fermented vegetables. If there is accompanying kidney dysfunction, it is advisable to minimize the intake of plant proteins and limit the consumption of plant-based proteins such as soy products.

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Written by Hu Lin
Nephrology
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IgA kidney disease symptoms

The clinical manifestations of IgA nephropathy are diverse. The most common clinical manifestations include episodic gross hematuria, asymptomatic hematuria, and proteinuria. Episodic gross hematuria often occurs several hours after an upper respiratory tract infection, or a day or two later. Patients may notice that their urine is dark tea-colored, brown, or fresh red, light red, and this type of gross hematuria tends to recur. The second type is asymptomatic microscopic hematuria, with or without proteinuria, also known as asymptomatic urinalysis. This is often discovered during physical examinations when patients show no symptoms and tests reveal hidden blood and protein positivity in the urine. The third major category is proteinuria, which in some patients may present as nephrotic syndrome-like proteinuria. The fourth is hypertension; the fifth, acute kidney injury; and the sixth, chronic kidney failure. Most patients with IgA nephropathy gradually progress to chronic kidney failure within 10 to 20 years of diagnosis.

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Nephrology
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Can patients with IgA nephropathy have sexual intercourse?

Patients with IgA nephropathy can engage in sexual intercourse, but there are certain prerequisites. Firstly, this disease is not contagious, and it will not be transmitted to the partner during intercourse. Secondly, there is not a significant relationship between renal function and sexual capability; patients with kidney diseases typically retain normal sexual and reproductive functions. However, since sexual activity requires a certain amount of physical strength, and in cases where the patient's condition is particularly severe, it might render the patient unable to engage in sexual activities. Therefore, if the patient does not have significant hypertension, severe edema, especially genital edema, pulmonary edema, or heart failure, they would be capable of engaging in sexual activities, and thus can have intercourse.

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Written by Zhou Qi
Nephrology
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Can IgA nephropathy stage 2 be cured?

IgA nephropathy is an immunopathological diagnostic term for chronic glomerulonephritis, indicating that the patient has chronic nephritis. In fact, chronic nephritis does not have a concept of complete cure. Stage two patients indicate that the inflammatory reaction within the glomerulus is not very severe, but the patient may also show more proteinuria. In most cases, the renal function of these patients is still normal, and it may be necessary to decide whether to choose medications such as corticosteroids based on the amount of proteinuria. If the patient responds well to medication, the proteinuria may significantly decrease, or even turn negative, but it cannot be completely cured, as this is a chronic disease, and there is also a possibility of relapse in the later stages of the disease. (Please follow the doctor's orders regarding medication use.)

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Written by Li Liu Sheng
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IgA kidney disease symptoms

IgA nephropathy is characterized by the deposition of IgA in the glomerular mesangial regions and is a common type of glomerulonephritis. It is also a major cause of uremia. IgA nephropathy typically affects adolescents. Once diagnosed, patients primarily experience recurrent macroscopic hematuria, especially after skin infections or respiratory infections, during which blood in the urine becomes more apparent. Of course, there can also be asymptomatic hematuria and increased urinary protein. Some patients with IgA nephropathy may also experience edema, particularly in the eyelids and facial area upon waking up in the morning, and in severe cases, there may be an increase in blood pressure and a decline in kidney function. It is essential for patients with IgA nephropathy to have regular follow-ups to monitor changes in routine urine tests, kidney function, and blood pressure, and to seek active treatment if the condition worsens.