The difference between rheumatic fever and rheumatoid arthritis

Written by Yang Ya Meng
Rheumatology
Updated on September 24, 2024
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Patients with rheumatoid arthritis primarily exhibit symmetrical swelling and pain in the small joints of both hands as the main clinical manifestations, with rarely any involvement of visceral organs. Blood tests can show elevated inflammatory markers, erythrocyte sedimentation rate (ESR), C-reactive protein, as well as positive rheumatoid factor, anti-CCP antibodies, and AK antibodies. These indicators can be considered as diagnostic for rheumatoid arthritis. Patients with rheumatic fever, in addition to joint pain, often have cardiac complications, such as mitral stenosis or chorea-like symptoms. The main difference between rheumatic fever and internal rheumatism is that patients with rheumatic fever often have cardiac complications.

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Written by Liu Li Ning
Rheumatology
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Rheumatic fever is not caused by a bacterium, but is a complication of a streptococcal infection.

Rheumatic fever is associated with Group A beta-hemolytic streptococcal infection and is a systemic inflammatory disease. The detailed pathogenesis is not yet very clear. Common clinical manifestations include joint pain, subcutaneous nodules, erythema marginatum, fever, chorea, and carditis. The characteristic of joint pain is that it generally does not leave joint deformities, and presents as migratory pain in the large joints of the limbs. Carditis can affect the heart valves and endocardium, primarily commonly involving the mitral or tricuspid valves. During the acute phase, penicillin antibiotics are needed for anti-infective treatment.

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Written by Yang Ya Meng
Rheumatology
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Is rheumatism hot compress useful?

Hot compresses for rheumatic diseases can alleviate joint pain by increasing the local skin temperature, and have a certain effect in relieving joint swelling and pain. However, they cannot fundamentally solve the problem. Rheumatic diseases still require chronic oral medication treatment. The commonly used medications for treating rheumatic diseases fall into three main categories. The first category consists of drugs that control pain symptoms, which we call anti-inflammatory analgesics, commonly including medications like celecoxib. Additionally, to control the progression of rheumatism, it is also necessary to use some immunosuppressants, with the most common being methotrexate and leflunomide. If the above methods are not effective, we may consider treatment with biologics. (Medication should be administered under the guidance of a doctor.)

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Written by Yang Ya Meng
Rheumatology
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The difference between rheumatic fever and rheumatoid arthritis

The main difference between rheumatic fever and rheumatoid arthritis is that in addition to symptoms of arthritis, rheumatic fever also presents with elevated anti-streptolysin O levels and valvular heart disease, with some patients displaying subcutaneous erythema and chorea-like symptoms. Rheumatoid arthritis, on the other hand, primarily manifests as joint pain, and rarely involves heart valve issues. Additionally, rheumatoid arthritis is characterized by elevated rheumatoid factor, anti-CCP antibodies, and anti-AkA antibodies as its main clinical features. Patients with rheumatoid arthritis also exhibit increased inflammatory markers. The key differences between rheumatic fever and rheumatoid arthritis lie in the different antibodies involved and the general association of rheumatic fever with cardiac involvement.

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Written by Yang Ya Meng
Rheumatology
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How to treat rheumatic fever arthritis?

Rheumatic fever joint pain initially can be treated with anti-inflammatory and analgesic medications. The most commonly used are non-steroidal anti-inflammatory drugs (NSAIDs), such as slow-release diclofenac sodium tablets. Since rheumatic fever is triggered by a streptococcal infection, if the streptococcus is not controlled, joint pain may reoccur. Therefore, fundamentally, an adequate course of anti-infection treatment is also needed. In the acute phase of rheumatic fever, antibiotics such as penicillin or second-generation cephalosporins can be used for a 10-14 day treatment. Subsequently, treatment may require sequential benzathine penicillin for possibly up to six months or more than a year. (Please use medications under the guidance of a doctor.)

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Written by Yang Ya Meng
Rheumatology
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Symptoms and Treatment of Rheumatic Fever

Patients with rheumatism often experience symptoms of upper respiratory tract infections in the early stages of the disease, such as fever and sore throat. Additionally, patients with rheumatism commonly exhibit migratory joint pain, primarily characterized by acute onset of redness, swelling, heat, pain, and limited mobility in the joints, but these can improve on their own. Patients with rheumatic fever often also suffer from carditis, which can include valvulitis, myocarditis, and pericarditis, with damage to the valves being the most common. Rheumatic fever may also present with ring-shaped erythema on the skin or subcutaneous nodules, and it can include chorea. The most common treatment for rheumatic fever is the intramuscular injection of penicillin. (Specific medication use should be carried out under the guidance of a doctor.)